Enhanced binding capacity of boronate affinity adsorbent via surface modification of silica by combination of atom transfer radical polymerization and chain-end functionalization for high-efficiency enrichment of cis-diol molecules

Analytica Chimica Acta
Wei WangYinmao Wei

Abstract

Boronate affinity materials have been widely used for specific separation and preconcentration of cis-diol molecules, but most do not have sufficient capacity due to limited binding sites on the material surface. In this work, we prepared a phenylboronic acid-functionalized adsorbent with a high binding capacity via the combination of surface-initiated atom transfer radical polymerization (SI-ATRP) and chain-end functionalization. With this method, the terminal chlorides of the polymer chains were used fully, and the proposed adsorbent contains dense boronic acid polymers chain with boronic acid on the chain end. Consequently, the proposed adsorbent possesses excellent selectivity and a high binding capacity of 513.6 μmol g(-1) for catechol and 736.8 μmol g(-1) for fructose, which are much higher than those of other reported adsorbents. The dispersed solid-phase extraction (dSPE) based on the prepared adsorbent was used for extraction of three cis-diol drugs (i.e., epinephrine, isoprenaline and caffeic acid isopropyl ester) from plasma; the eluates were analyzed by HPLC-UV. The reduced amount of adsorbent (i.e., 2.0 mg) could still eliminate interferences efficiently and yielded a recovery range of 85.6-101.1% with relative sta...Continue Reading

References

Dec 26, 2001·Chemical Reviews·K Matyjaszewski, J Xia
Sep 11, 2007·Bioorganic & Medicinal Chemistry·Pilar Rodriguez LoaizaPeter Gmeiner
Apr 21, 2010·Journal of Chromatography. a·Thummaruk SuksrichavalitLei Ye
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Mar 19, 2011·Analytica Chimica Acta·Cafer CakalPerihan Caglar
Jan 22, 2014·ACS Applied Materials & Interfaces·Zhifeng XuLei Ye

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Citations

Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jun-Zi WuLi-Min Zhu
Aug 16, 2018·Journal of Agricultural and Food Chemistry·Mingming WangRuijin Yang

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