Enhanced bioactivity of titanium-coated polyetheretherketone implants created by a high-temperature 3D printing process

Biofabrication
Hyun-Do JungSuk-Hee Park

Abstract

Polyetheretherketone (PEEK), one of the potential alternatives to metallic materials for implants, necessarily involves high temperature process conditions to be three-dimensionally (3D) printed. We developed a 3D printing setup equipped with thermally stabilized modules of the printing nozzle and building chamber, by which the PEEK implants could be successfully manufactured. Under optimized printing conditions, the maximal mechanical strength of the 3D printed sample attained over 80% of the original bulk property of PEEK. To enhance the interfacial biocompatibility, the as-printed implants were postprocessed with titanium (Ti) sputtering. The Ti-coated surfaces were evaluated through characterization studies of x-ray diffraction spectra, microscopic topographies, and wetting properties. For the in vitro tests, preosteoblasts were cultured on the developed PEEK-Ti structures and evaluated in terms of cell adhesion, proliferation, and osteogenic differentiation. In addition, the bone regeneration capability of the PEEK-Ti implants was confirmed by animal experiments using a rabbit tibia defect model for a period of 12 weeks. In the overall in vitro and in vivo tests, we confirmed the superior bioactivities of the Ti-modified a...Continue Reading

References

Feb 1, 1992·Journal of Biomedical Materials Research·K A JockischK Merritt
Aug 1, 1997·Journal of Biomedical Materials Research·T W LinD S Hungerford
Nov 20, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·T Albrektsson
Jun 29, 1999·Journal of Biomaterials Science. Polymer Edition·O NoisetJ Marchand-Brynaert
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·S W HaH Vonmont
Jun 21, 2005·Journal of Materials Science. Materials in Medicine·D BriemJ M Rueger
Jul 20, 2005·Biomaterials·E LeclercC Legallaisa
Aug 10, 2007·Biomaterials·Steven M Kurtz, John N Devine
Sep 2, 2008·Journal of Biomaterials Applications·Ill Yong KimSung Baek Cho
May 15, 2010·International Journal of Computer Assisted Radiology and Surgery·F RengierF L Giesel
Mar 16, 2012·International Journal of Nanomedicine·Xiaomian WuShicheng Wei
Aug 7, 2012·Journal of Biomedical Materials Research. Part a·Sargon BarkarmoVictoria Stenport
Sep 22, 2012·Journal of Biomechanics·Xuanliang N DongXiaodu Wang
Jan 3, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Declan M DevineSimon G Pearce
Feb 16, 2013·Journal of Biomedical Materials Research. Part a·Afsaneh Rabiei, Stefan Sandukas
Nov 10, 2013·Journal of Materials Science. Materials in Medicine·Jasmin Waser-AlthausKirsten Peters
Apr 2, 2014·International Journal of Molecular Sciences·Rui Ma, Tingting Tang
May 23, 2014·Nature Materials·Matthew J DalbyRichard O C Oreffo
Aug 6, 2014·Nature Biotechnology·Sean V Murphy, Anthony Atala
Feb 14, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hyun-Do JungYuri Estrin
Jul 3, 2015·Acta Biomaterialia·S M GiannitelliA Rainer
Oct 22, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Swee Leong SingFlorencia Edith Wiria
Nov 7, 2015·European Journal of Gastroenterology & Hepatology·Stephanie Y LeeDouglas L Nguyen
Jan 12, 2016·Journal of Physics. Condensed Matter : an Institute of Physics Journal·V D NguyenP Schall
Jun 1, 2016·The Spine Journal : Official Journal of the North American Spine Society·Byung Jo Victor YoonCeleste Abjornson
Jun 5, 2016·Journal of Materials Science. Materials in Medicine·Ivan Vladislavov PanayotovJacques Yachouh
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Toshiki MiyazakiYuki Shirosaki
Dec 28, 2016·ACS Biomaterials Science & Engineering·Murat GuvendirenJoachim Kohn
May 6, 2017·ACS Applied Materials & Interfaces·Meiling ChenXuanyong Liu
May 31, 2017·Advanced Healthcare Materials·Stuart KyleIain S Whitaker

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Citations

Nov 17, 2020·Biomedical Engineering Letters·Tae-Sik JangHyun-Do Jung
Feb 4, 2021·Advanced Functional Materials·Charlotte GarotCatherine Picart
May 27, 2020·Dental Materials : Official Publication of the Academy of Dental Materials·Prabaha SikderSarit B Bhaduri
Apr 16, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Cemile BasgulSteven M Kurtz

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