PMID: 7334457Sep 1, 1981Paper

Enhanced bioavailability of digoxin by gamma-cyclodextrin complexation

Journal of Pharmacobio-dynamics
K UekamaM Tsuruoka

Abstract

Inclusion complex of digoxin with gamma-cyclodextrin (gamma-CyD) in 1:4 molar ratio was prepared, and its dissolution and absorption behaviors were compared with those of digoxin alone. The dissolution rate of digoxin in water was found to be markedly increased by gamma-CyD complexation. Bioavailability of digoxin following the oral administration of gamma-CyD complex to dogs was 5.4 times as much as that of digoxin alone. The present data did indicate improvement of dissolution and absorption characteristics of digoxin by inclusion complexation, suggesting the decrease in dose in oral digoxin therapy.

Citations

Jan 5, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kaneto Uekama
May 7, 2015·International Journal of Molecular Sciences·Ryota UchidaTakashi Hirota
Jun 9, 2009·Journal of Pharmaceutical Sciences·Alfonso Pérez-GarridoAmalio Garrido Escudero
Sep 25, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rebecca L CarrierImran Ahmed
Apr 18, 2013·Biotechnology and Bioengineering·Ece D GamsizRebecca L Carrier
Sep 3, 2009·Biotechnology and Bioengineering·Ece Dilber GamsizRebecca Lyn Carrier
Jul 22, 2004·International Journal of Pharmaceutics·Masako OdaBruce J Aungst
Dec 4, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kaneto Uekama
Aug 12, 2004·Chemical & Pharmaceutical Bulletin·Kaneto Uekama
Oct 1, 1982·The Journal of Pharmacy and Pharmacology·K UekamaK Ikeda

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