Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Wei WuLi Que

Abstract

The main purpose of this study was to prepare lipid-based self-microemulsifying drug delivery system (SMEDDS) to improve peroral bioavailability of silymarin. SMEDDS was a system consisting of silymarin, Tween 80, ethyl alcohol, and ethyl linoleate. Particle size change of the microemulsion was evaluated upon dilution with aqueous media and loading with incremental amount of silymarin. In vitro release was investigated by a dialysis or an ultrafiltration method. Results showed that release of silymarin from SMEDDS was limited, incomplete, and typical of sustained characteristics. Pharmacokinetics and bioavailability of silymarin suspension, solution, and SMEDDS were evaluated and compared in rabbits. Plasma silybin, which was treated as the representing component of silymarin, was determined by high-performance liquid chromatography. After gavage administration of silymarin suspension, plasma silybin level was very low and fell below limit of detection 4h after. As for silymarin solution and SMEDDS, double peak of maximum concentrations were observed, which was characteristic of enterohepatic circulation. Relative bioavailability of SMEDDS was dramatically enhanced in an average of 1.88- and 48.82-fold that of silymarin PEG 400...Continue Reading

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Citations

Jun 10, 2011·Archives of Pharmacal Research·Rabea ParveenSayeed Ahmad
Jul 3, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andreas Bernkop-Schnürch
Dec 21, 2010·Acta Pharmacologica Sinica·Rui-ling DuanZhi-rong Zhang
Apr 24, 2008·AAPS PharmSciTech·Marta Fernandez-TarrioAngel Concheiro
Jul 25, 2009·AAPS PharmSciTech·Swati A GuhagarkarPadma V Devarajan
Dec 17, 2009·AAPS PharmSciTech·Vijaykumar NekkantiRaviraj Pillai
Feb 26, 2010·AAPS PharmSciTech·Adhvait R DixitSamir G Patel
Jun 19, 2013·AAPS PharmSciTech·N S Desai, M S Nagarsenker
Jan 1, 2014·International Journal of Nanomedicine·Waheed M IbrahimAlaa Eldeen B Yassin
Jul 26, 2014·Journal of Functional Biomaterials·Sonia TrombinoRoberta Cassano
Mar 1, 2012·Drug Development and Industrial Pharmacy·Md Akhlaquer RahmanZeenat Iqbal
Nov 18, 2011·Drug Development and Industrial Pharmacy·Mithun Mohanraor BandivadekaSoumya Koppikar
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