Enhanced but delayed axonal sprouting of the commissural/associational pathway following a combined entorhinal cortex/fimbria fornix lesion

The Journal of Comparative Neurology
P E Schauwecker, T H McNeill

Abstract

From previous lesion studies of the hippocampus it has been reported that axons of the commissural/associational pathway expand their termination zone in the molecular layer of the dentate gyrus by 20-25% in response to loss of input from the entorhinal cortex. However, although much is known about the response of the commissural/associational pathway with regard to extent, latency, and speed of the reinnervation response following an entorhinal cortex lesion, little is known about how the loss of additional afferent systems might modulate this response. To address this issue, we examined at 14, 30, and 45 days postlesion, the sprouting of commissural/associational afferents following either a unilateral fimbria fornix transection, a unilateral entorhinal cortex lesion, or combined lesions of both the entorhinal cortex and the fimbria fornix. Loss of septal innervation to the hippocampus was assessed using the cholinesterase stain, whereas sprouting from the commissural/associational pathway was determined from Holmes fiber-stained sections. In addition, the Timms stain was used to examine the time course of the loss of terminal fields of the various zinc-containing afferent systems within the hippocampus. Following the removal...Continue Reading

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Citations

Jun 26, 1998·Brain Research. Brain Research Reviews·B Connor, M Dragunow
Sep 23, 2003·Brain Research. Molecular Brain Research·Mitch PriceJonathan R Day
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M H BassantJ M Billard
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julia V PerederiyGary L Westbrook
Oct 17, 2013·Journal of Neuropathology and Experimental Neurology·Robert SimanYina Dong
Jul 21, 2004·Journal of Neuroscience Methods·Teresa Elena MuñozJonathan R Day
Feb 8, 2006·Journal of Neuroscience Methods·Christopher J FredericksonArtur Krezel

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