Enhanced calcitonin release in chronic renal failure depending on the absence of severe secondary hyperparathyroidism

Nephron
H MulderG J den Ottolander

Abstract

In 27 patients with end-stage chronic renal failure an elevated calcitonin (CT) and parathyroid hormone was found. On stimulation with Ca i.v. there were 9 cases in whom delta CT proved to be higher than the maximal response of 50 pg ml-1 in controls. Supranormal CT responses were found predominantly in patients with normal alkaline phosphatase, who as a group increased their CT from 94.5 +/- 61 to 142.0 +/- 94 pg ml-1 (p less than 0.02). In contrast to this, patients with elevated alkaline phosphatase who also had a higher level of parathyroid hormone maintained unchanged CT on Ca stimulation. It is concluded that in chronic renal failure with severe secondary hyperparathyroidism, delta CT on stimulation is normal, while an enhanced delta CT often exists when hyperparathyroidism is of insufficient degree to cause a raised alkaline phosphatase.

Citations

Mar 1, 1988·Calcified Tissue International·T Onishi, L J Deftos
Jan 1, 1995·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Y M LüK H Liang
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Jun 10, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kyra A BorchhardtGere Sunder-Plassmann
Feb 23, 2018·Journal of Veterinary Internal Medicine·D H N van den BroekR E Jepson

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