Enhanced calcium mobilization in rat ventricular myocytes during the onset of pressure overload-induced hypertrophy

American Journal of Physiology. Heart and Circulatory Physiology
Beatriz M R CarvalhoJosé W M Bassani

Abstract

Early cardiovascular changes evoked by pressure overload (PO) may reveal adaptive strategies that allow immediate survival to the increased hemodynamic load. In this study, systolic and diastolic Ca(2+) cycling was analyzed in left ventricular rat myocytes before (day 2, PO-2d group) and after (day 7, PO-7d group) development of hypertrophy subsequent to aortic constriction, as well as in myocytes from time-matched sham-operated rats (sham group). Ca(2+) transient amplitude was significantly augmented in the PO-2d group. In the PO-7d group, intracellular Ca(2+) concentration ([Ca(2+)](i)) was reduced during diastole, and mechanical twitch relaxation (but not [Ca(2+)](i) decline) was slowed. In PO groups, fractional sarcoplasmic reticulum (SR) Ca(2+) release at a twitch, SR Ca(2+) content, SR Ca(2+) loss during diastole, and SR-dependent integrated Ca(2+) flux during twitch relaxation were significantly greater than in sham-operated groups, whereas the relaxation-associated Ca(2+) flux carried by the Na(+)/Ca(2+) exchanger was not significantly changed. In the PO-7d group, mRNA levels of cardiac isoforms of SR Ca(2+)-ATPase (SERCA2a), phospholamban, calsequestrin, ryanodine receptor, and NCX were not significantly altered, but t...Continue Reading

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Citations

Apr 21, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Subash C GuptaPaul M L Janssen
May 31, 2011·Frontiers in Bioscience (Scholar Edition)·Kaylan M Haizlip, Paul M L Janssen
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Apr 13, 2013·Journal of Molecular and Cellular Cardiology·José W M Bassani, Rosana A Bassani
Jun 30, 2012·Medical Engineering & Physics·Robson R SilvaMarcia A S Bissaco
Feb 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Halvor K MørkWilliam E Louch
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Aug 22, 2020·Circulation Research·Senka Ljubojevic-HolzerDonald M Bers
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Roberta BerniDonatella Stilli
Mar 28, 2008·Molecular and Cellular Biochemistry·Vittoria CarnicelliRiccardo Zucchi

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