Enhanced cancer cell invasion caused by fibroblasts when fluid flow is present

Biomechanics and Modeling in Mechanobiology
Jone UrdalSteinar Evje

Abstract

It has been demonstrated that interstitial fluid (IF) flow can play a crucial role in tumor cell progression. Swartz and collaborators (Cancer Cell 11: 526-538, Shields et al. 2007) demonstrated that cells that secrete the lymphoid homing chemokines CCL21/CCL19 and express their receptor CCR7 could use flow to bias the secreted chemokine, causing pericellular gradients that stimulate cells to migrate in the direction of the flow. In a further work by Shieh et al. (Cancer Res 71: 790-800, 2011), a synergetic enhancement of tumor cell invasion caused by interaction between tumor cells and fibroblasts in the presence of fluid flow was reported. In the present work, we extend a previous proposed cell-fluid mathematical model for autologous chemotaxis (Chem Eng Sci 191: 268-287, Waldeland and Evje 2018) to also include fibroblasts. This results in a cell-fibroblast-fluid model. Motivated by the experimental findings by Shieh et al, the momentum balance equation for the fibroblasts involves (1) a stress term that accounts for chemotaxis in the direction of positive gradients in secreted growth factor TGF-[Formula: see text]; (2) a fibroblast-ECM interaction term; (3) a cancer cell-fibroblast interaction term. Imposing reasonable simp...Continue Reading

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Citations

Nov 14, 2019·Cellular and Molecular Bioengineering·Steinar Evje, Jahn Otto Waldeland
Jun 5, 2021·Journal of Theoretical Biology·Jahn Otto WaldelandSteinar Evje

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