Enhanced cancer metastasis after monocrotaline-induced lung injury

Toxicology and Applied Pharmacology
L VincicJ M Kay

Abstract

The lung is a target in several models of environmentally induced injury and is also a common site for the growth of metastases from circulating cancer cells. In these experiments, we have tested the hypothesis that pulmonary damage can facilitate the metastasis of cancer to the lung. We have studied the effect of monocrotaline-induced lung injury on the retention and metastasis of intravenously injected Walker carcinosarcoma 256 cells in the lung and the effect of this injury on spontaneous metastasis in animals with intramuscular tumor transplants. Female Wistar rats were given a single subcutaneous injection of monocrotaline (60 mg/kg). The degree of lung injury after monocrotaline was assessed by bronchoalveolar lavage, by histological and ultrastructural examination, and by measurement of right ventricular hypertrophy. To assess the effects of monocrotaline on metastasis, animals were injected iv with 2 X 10(7) [125I]iododeoxyuridine-labeled or unlabeled Walker 256 carcinosarcoma cells at various periods of time (1 day to 20 days) after monocrotaline. The retention of labeled cells was determined by gamma counts of lungs 24 hr after injection. There was a direct correlation between the severity of lung injury and the numbe...Continue Reading

References

Apr 1, 1986·Clinical & Experimental Metastasis·F W OrrL Young
Sep 1, 1987·The American Review of Respiratory Disease·R A Roth, P E Ganey
Dec 1, 1988·Toxicology and Applied Pharmacology·S M White, R A Roth
Sep 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·A MolteniN H Solliday
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N S SargentM M Burger
May 1, 1988·Clinical & Experimental Metastasis·F W OrrI Y Adamson
Mar 1, 1987·Current Problems in Surgery·I J Fidler, C M Balch
Jan 1, 1987·Journal of Toxicology and Environmental Health·L H BrunerR A Roth
Jan 1, 1984·Cancer Metastasis Reviews·G J Gasic
Nov 1, 1983·Experimental Lung Research·T SugitaJ T Reeves
Mar 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G L Nicolson
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·R H KramerG L Nicolson

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Citations

Feb 24, 2000·The Journal of Pathology·F W OrrD M Nance
Nov 1, 1992·Cancer Metastasis Reviews·R LafrenieF W Orr
Oct 20, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·A E Schultze, R A Roth
Aug 1, 1993·Cell Biophysics·R M LafrenieF W Orr
Jun 1, 1991·Toxicology and Applied Pharmacology·A E SchultzeR A Roth
Jan 23, 2010·Chemical Research in Toxicology·Yu-Qi HeZheng-Tao Wang

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