Enhanced cell growth on 3D graphene scaffolds implanted with nitrogen ions

Biointerphases
Mengli ZhaoHanqing Gu

Abstract

One of the key challenges in engineering tissues for cell-based therapies is developing biocompatible scaffold materials to direct cell behavior. In this paper, the cytocompatibilities of a flexible three-dimensional graphene scaffold (3D-G) and the same scaffold implanted with nitrogen ions (N+/3D-G) are compared using an in vitro assay based on 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The N+/3D-G samples were prepared from low-temperature hydrothermally synthesized flexible 3D-G by ion implantation and were found to display improved adhesion and proliferation of rat osteoblast and mouse fibroblast cells. In particular, the N+/3D-G sample with a nitrogen content of ∼10% showed the highest levels of cell viability and proliferation. The flexible N+/3D-G has potential applications as a biocompatible scaffold material that provides improved surface area and hydrophilic groups for cell growth and proliferation.

References

Feb 19, 2013·Advanced Materials·Han HuJieshan Qiu
Jan 15, 2015·Nanoscale·Shun MaoJunhong Chen
Mar 31, 2015·ACS Applied Materials & Interfaces·Jun Kit WangCleo Choong
Aug 17, 2016·Journal of Biomedical Materials Research. Part a·Gaurav LalwaniBalaji Sitharaman
Nov 23, 2016·Gene Therapy·M VincentK Kostarelos
Jan 22, 2017·Journal of Materials Science. Materials in Medicine·Hossein Aghajani, Mohsen Sadeghpour Motlagh
Sep 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yulan WangYufeng Zhang

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