Enhanced cell ingrowth and proliferation through three-dimensional nanocomposite scaffolds with controlled pore structures.

Biomacromolecules
Kee-Won LeeLichun Lu

Abstract

We present enhanced cell ingrowth and proliferation through cross-linked three-dimensional (3D) nanocomposite scaffolds fabricated using poly(propylene fumarate) (PPF) and hydroxyapatite (HA) nanoparticles. Scaffolds with controlled internal pore structures were produced from computer-aided design (CAD) models and solid freeform fabrication (SFF) technique, while those with random pore structures were fabricated by a NaCl leaching technique for comparison. The morphology and mechanical properties of scaffolds were characterized using scanning electron microscopy (SEM) and mechanical testing, respectively. Pore interconnectivity of scaffolds was assessed using X-ray microcomputed tomography (micro-CT) and 3D imaging analysis. In vitro cell studies have been performed using MC3T3-E1 mouse preosteoblasts and cultured scaffolds in a rotating-wall-vessel bioreactor for 4 and 7 days to assess cell attachment, viability, ingrowth depth, and proliferation. The mechanical properties of cross-linked nanocomposite scaffolds were not significantly different after adding HA or varying pore structures. However, pore interconnectivity of PPF/HA nanocomposite scaffolds with controlled pore structures has been significantly increased, resulting...Continue Reading

References

Feb 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L A FeldkampM Kleerekoper
Sep 1, 1970·Journal of Biomedical Materials Research·S F HulbertF H Stelling
Oct 31, 2000·Biomaterials·K J BurgJ F Kellam
Nov 9, 2000·Biomaterials·D W Hutmacher
Jun 26, 2002·Annals of the New York Academy of Sciences·T-M G ChuD G Orton
Jul 19, 2002·Journal of Biomedical Materials Research·Vassilios I SikavitsasAntonios G Mikos
Sep 18, 2004·Journal of Biomedical Materials Research. Part a·Michael J MooreMichael J Yaszemski
Apr 30, 2005·Biomaterials·Vassilis Karageorgiou, David Kaplan
Jul 8, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yu-Fen ChouBenjamin M Wu
Jul 9, 2005·Nature Materials·Scott J Hollister
Oct 20, 2005·Journal of Bioscience and Bioengineering·Yoshihiro ItoOh Hyeong Kwon
Oct 31, 2006·Journal of Biomedical Materials Research. Part a·Sang-Soo KimByung-Soo Kim
Mar 6, 2007·Biomaterials·Anthony C JonesMark A Knackstedt
Jun 30, 2007·Journal of Biomedical Materials Research. Part a·Sashka DimitrievskaL'Hocine Yahia
Aug 10, 2007·Journal of Nanoscience and Nanotechnology·Surya Singh, Suprakas Sinha Ray
Jun 25, 2008·Journal of Materials Science. Materials in Medicine·Xiufeng XiaoQiongyu Huang

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Citations

Dec 12, 2012·Tissue Engineering. Part a·Viviane LuangphakdyGeorge F Muschler
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jian-Zheng WangYue-Zhong Meng
Apr 7, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Steven M RomanelliIpsita A Banerjee
Jun 8, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Anne Ylä-SoininmäkiHannu T Aro
Sep 11, 2012·Journal of Biomedical Materials Research. Part a·Roohollah BagherzadehLingxue Kong
Feb 22, 2013·Journal of Biomedical Materials Research. Part a·Roohollah BagherzadehLingxue Kong
Jul 20, 2011·Journal of Polymer Science. Part B, Polymer Physics·Bret D UleryCato T Laurencin
Apr 26, 2012·Scanning·Juliana Tsz Yan Lee, King Lau Chow
Apr 5, 2013·Journal of Biomedical Materials Research. Part a·Roohollah BagherzadehLingxue Kong
Nov 26, 2013·Materials Science & Engineering. C, Materials for Biological Applications·R DoratiB Conti
Nov 5, 2013·Acta Biomaterialia·S M GiannitelliA Rainer
Nov 11, 2010·Lab on a Chip·Christina L RandallDavid H Gracias
Aug 2, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Aline M Thomas, Lonnie D Shea
Aug 12, 2016·Journal of Biomedical Materials Research. Part a·Ji GuoLichun Lu
Dec 22, 2016·The Analyst·Adeline Huiling LooMartin Pumera
Jan 27, 2017·Journal of Biomaterials Science. Polymer Edition·Jordan E TrachtenbergAntonios G Mikos
May 1, 2018·Journal of Biomedical Materials Research. Part a·Wei WuLichun Lu
Nov 14, 2018·Journal of Biomedical Materials Research. Part a·Jingfeng LiLichun Lu
Jul 28, 2013·Biofabrication·Miguel CastilhoElke Vorndran
Apr 24, 2012·Nature Chemistry·Mark D SymesLeroy Cronin
Apr 12, 2012·Journal of Biomaterials Applications·Leonardo CioccaRoberto Scotti
Oct 30, 2019·Bioengineering·Christina KryouIoanna Zergioti
May 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qi GaoChangyou Gao

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