PMID: 9159532Apr 1, 1997Paper

Enhanced co-stimulatory ability of synovial fluid accessory cells in rheumatoid arthritis

British Journal of Rheumatology
S E RobertsonP A Bacon

Abstract

We have established in vitro assays that allow the examination of co-stimulatory function of rheumatoid arthritis (RA) antigen-presenting cells (APC). Synovial fluid (SF) and peripheral blood (PB) APC co-stimulatory ability was compared in the activation of peptide-specific human T-cell clones. T-cell receptor (TCR) stimulation by peptide or anti-CD3 antibody allowed the direct comparison of SF and PB APC co-stimulatory activity, separately from their ability to process antigen. SF APC from 15 RA patients consistently enhanced T-cell proliferation when compared to their PB counterparts. Moreover, increasing the numbers of PB APC present resulted in only a minor increase in T-cell proliferation, failing to achieve levels stimulated by SF APC. We propose that the enhanced co-stimulatory function of synovial APC may be a significant factor in the persistence of local immune responses in RA.

Citations

Oct 30, 1999·Immunology and Cell Biology·A R Pettit, R Thomas
Nov 6, 2002·Journal of Cellular and Molecular Medicine·Andra BalanescuDenisa Predeteanu
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S TakemuraC M Weyand

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.