Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia

The Journal of Clinical Investigation
H M KwonAmir Lerman

Abstract

Coronary arteries contain a network of vasa vasorum in the adventitia. The three-dimensional anatomy of the vasa vasorum in early coronary atherosclerosis is unknown. This study was designed to visualize and quantitate the three-dimensional spatial pattern of vasa vasorum in normal and experimental hypercholesterolemic porcine coronary arteries, using a novel computed tomography technique. Animals were killed after being fed either a high cholesterol diet (n = 4) or a control diet (n = 4) for 12 wk. The proximal left anterior descending coronary artery was removed from the heart, scanned, and reconstructed, and quantitation of vasa vasorum density was performed. Two different types of vasa vasorum were defined: first-order vasa vasorum ran longitudinally parallel to the vessel and second-order originated from first-order vasa circumferentially around the vessel wall. Compared with controls in hypercholesterolemic coronary arteries, there was a significant increase in the area of the vessel wall (3.86+/-0.22 vs. 8.07+/-0.45 mm2, respectively, P < 0.01) and in the density of vasa vasorum (1. 84+/-0.05/mm2 vs. 4.73+/-0.24/mm2; respectively, P = 0.0001). This occurred especially by an increase of second-order vasa vasorum and disor...Continue Reading

References

Dec 1, 1990·Immunology Today·C M Petersen, S K Moestrup
Jun 1, 1991·European Journal of Clinical Investigation·J F MartinS Moncada
Sep 1, 1989·American Journal of Respiratory Cell and Molecular Biology·J S Huang
May 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D D Heistad, M L Armstrong
Apr 22, 1994·Science·P C BrooksD A Cheresh
Feb 1, 1995·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S G BarkerJ F Martin
Sep 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·F LupuE K Kruithof
Jan 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S G BarkerJ F Martin
Nov 1, 1996·Catheterization and Cardiovascular Diagnosis·J M Isner
Apr 1, 1951·The Journal of Pathology and Bacteriology·E GEIRINGER

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Citations

Dec 28, 1999·Herz·A Lerman, E L Ritman
Apr 5, 2001·Current Atherosclerosis Reports·K S Moulton
Sep 17, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jagat Narula
Jun 25, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Valentin Fuster, Torsten P Vahl
Jul 17, 2007·Cardiovascular Research·Erik L Ritman, Amir Lerman
Jan 20, 2010·JACC. Cardiovascular Imaging·Manabu KashiwagiTakashi Akasaka
Jun 29, 2001·International Journal of Radiation Oncology, Biology, Physics·M KollumR Waksman
Jun 23, 2001·Journal of the American College of Cardiology·D W Losordo, J M Isner
May 3, 2002·Journal of the American College of Cardiology·Joerg HerrmannAmir Lerman
Mar 20, 2003·Journal of the American College of Cardiology·Prediman K Shah
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Karen S MoultonJudah Folkman
Jun 29, 2010·European Heart Journal·Diego MoguillanskyFlordeliza S Villanueva
Mar 15, 2011·European Heart Journal·Jean-Baptiste MichelGerard Pasterkamp
Sep 9, 2006·Current Opinion in Lipidology·Karen S Moulton
Jul 11, 2006·Investigative Radiology·David E GoertzAntonius F W van der Steen
Jul 6, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Damir HamamdzicRobert L Wilensky
Nov 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mary Jo Mulligan-Kehoe
Jun 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Mark W MajeskyGuenter Daum
Mar 20, 2010·Journal of Angiogenesis Research·Lyubomir ZagorchevThierry Couffinhal
Nov 7, 2013·International Journal of Molecular Sciences·Aleksandra Jaźwińska-KozubaStefanie M Bode-Böger
Jun 15, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Carlos L AlviarJuan F Granada
Mar 10, 2001·Biochemical and Biophysical Research Communications·F de NigrisC Napoli
Apr 1, 2014·Pediatric Rheumatology Online Journal·Akiko Hamaoka-OkamotoKenji Hamaoka
Jun 17, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gerrit L ten KateArend F L Schinkel
Feb 22, 2005·European Radiology·T LeinerJ van Engelshoven
Jul 8, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·D E GoertzA F W van der Steen
Aug 20, 2004·Radiology·Alexander Claus LangheinrichRainer Maria Bohle
Apr 24, 2004·Radiology·Alexander Claus LangheinrichHans Hölschermann
May 27, 2015·International Journal of Molecular Sciences·Junyan XuGuo-Ping Shi
Dec 15, 2015·European Heart Journal Cardiovascular Imaging·Kyoung-Ha ParkAmir Lerman
Jan 15, 2016·European Heart Journal Cardiovascular Imaging·Fernando Alfonso, José María De la Torre Hernández
Jul 13, 2011·The American Journal of the Medical Sciences·Sona MitraJawahar L Mehta
Jan 26, 2016·Nitric Oxide : Biology and Chemistry·Alexander KollauBernd Mayer
Jan 15, 2013·Trends in Cardiovascular Medicine·Mary Jo Mulligan-Kehoe
Feb 19, 2002·Kidney International·Michael D BentleyLilach O Lerman
Aug 8, 2012·Trends in Cardiovascular Medicine·Benoît Ho-Tin-Noé, Jean-Baptiste Michel

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