Enhanced correlation between quantitative ultrasound and structural and mechanical properties of bone using combined transmission-reflection measurement

The Journal of the Acoustical Society of America
Liangjun LinYi-Xian Qin

Abstract

Quantitative ultrasound (QUS) is capable of predicting the principal structural orientation of trabecular bone; this orientation is highly correlated with the mechanical strength of trabecular bone. Irregular shape of bone, however, would increase variation in such a prediction, especially under human in vivo measurement. This study was designed to combine transmission and reflection modes of QUS measurement to improve the prediction for the structural and mechanical properties of trabecular bone. QUS, mechanical testing, and micro computed tomography (μCT) scanning were performed on 24 trabecular bone cubes harvested from a bovine distal femur to obtain the mechanical and structural parameters. Transmission and reflection modes of QUS measurement in the transverse and frontal planes were performed in a confined 60° angle range with 5° increment. The QUS parameters, attenuation (ATT) and velocity (UV), obtained from transmission mode, were normalized to the specimen thickness acquired from reflection mode. Analysis of covariance showed that the combined transmission-reflection modes improved prediction for the structural and Young's modulus of bone in comparison to the traditional QUS measurement performed only in the medial-la...Continue Reading

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Sep 6, 2020·The Spine Journal : Official Journal of the North American Spine Society·Zach PenningtonDaniel M Sciubba
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Alice AcciaioliMassimiliano Baleani

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