Jan 10, 2008

Enhanced cortisol suppression in eating disorders with impulsive personality features

Psychiatry Research
Marina Díaz-MarsáEric Hollander

Abstract

Evidence of both blunted and enhanced cortisol suppression with the dexamethasone test (DST) is available in eating disorders (ED), suggesting that different subtypes of ED might be characterized by distinct neurobiological stress response dysfunctions. Other evidence indicates that ED patients with impulsive clinical features might have enhanced cortisol suppression similar to patients with impulsive personality disorders. A group of 52 patients with restrictive anorexia, binge eating-purging anorexia and bulimia nervosa were studied with a very low dose (0.25 mg) dexamethasone test and measures of phenomenology, personality and impulsivity. Patients with bulimic symptoms had significantly higher rates of cortisol suppression than controls and than restrictive anorectic patients. Percent cortisol suppression showed a strong and significant correlation with the patient's score on the Barratt Impulsiveness Scale. A hypersensitive cortisol response to dexamethasone, which might reflect hypothalamic-pituitary-adrenal axis dysfunctions might be specifically associated with impulsive subtypes of eating disorders.

  • References16
  • Citations19

References

  • References16
  • Citations19

Citations

Mentioned in this Paper

Anorexia
Biological Adaptation to Stress
Borderline Personality Disorder
Structural Clinical Interview for DSM-III
Visual Suppression
Menstrual Periods Stopped for Over 6 Months
Purging
Osteochondritis of the Talus
Metabolic Inhibition
Anorexia Symptom

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