Enhanced cytotoxic T-cell function and inhibition of tumor progression by Mst1 deficiency.

FEBS Letters
Kaneki YasudaTatsuo Kinashi

Abstract

Mammalian ste-20 like kinase Mst1 plays important roles during apoptosis, proliferation, cell polarity, and migration. Here, we report a novel role of Mst1 for cytotoxic T-cell responses and tumor suppression. The defect of Mst1 caused decreased levels of FoxO, and promoted cytotoxicity in vitro. Mst1(-/-) cytotoxic T cells also exhibited enhanced T-bet expression that was associated with elevated expression levels of IFNγ and granzyme B. Moreover, Mst1(-/-) cytotoxic T cells suppressed tumor growth in vivo. The data suggest that Mst1 inhibits cytotoxicity via T-bet suppression by FoxO1 and FoxO3a. Thus, Mst1 is a potential therapeutic target for tumor immunotherapy.

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Citations

Nov 28, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sahar Bagherzadeh YazdchiWoong-Kyung Suh
Feb 12, 2020·Blood Advances·Lu HuangChaohong Liu
Mar 31, 2018·Cancers·Zaid TahaXiaolong Yang
May 6, 2019·Cells·Takayoshi Yamauchi, Toshiro Moroishi
Feb 21, 2018·Frontiers in Immunology·Jiali ChengChaohong Liu
Nov 10, 2020·Immune Network·Antoine BouchardWoong-Kyung Suh

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