Enhanced deposition of predominantly type I collagen in myocardial disease

Journal of Molecular and Cellular Cardiology
J E BishopG J Laurent

Abstract

The myocardium consists of a muscle fibre array surrounded and interspersed by a network of connective tissue, principally collagen, which maintains the functional integrity of the heart. Changes in collagen composition may therefore contribute to altered ventricular function. Collagen composition was examined in cardiac tissue from 15 patients undergoing orthotopic cardiac transplantation. Of these, 10 had severely impaired left ventricular function due to coronary artery disease. The remaining five had dilated cardiomyopathy. Normal heart tissue was taken at autopsy from 25 patients who died of causes unrelated to cardiovascular disease. Left ventricular collagen concentration, estimated from hydroxyproline levels, increased from 48.6 +/- 4.1 mg/g dry weight of tissue in the control group to 95.3 +/- 9.7 mg/g (P less than 0.01) in patients with dilated cardiomyopathy and to 63.5 +/- 9.8 mg/g in the coronary artery disease group. This increase was attributable to an increase in absolute concentrations of both type I and III collagen, determined by separation of cyanogen bromide peptides by sodium dodecyl sulphate polyacrylamide gel electrophoresis. However, there was a significant decrease in the proportion of type III collage...Continue Reading

Citations

Dec 22, 1993·Molecular and Cellular Biochemistry·V PelouchN S Dhalla
Jun 7, 1995·Molecular and Cellular Biochemistry·J AusmaM Borgers
Sep 8, 1993·Molecular and Cellular Biochemistry·S C TyagiK T Weber
Jan 2, 2014·Journal of Cardiovascular Translational Research·Reid G HendryDavid J Marchant
May 1, 1995·Journal of the American College of Cardiology·M M MarijianowskiA E Becker
Apr 1, 1996·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·M ChelloA R Marchese
Mar 1, 1996·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·R J van SuylenF T Bosman
Apr 1, 1996·The American Journal of Cardiology·S M SchwartzT J Kulik
Aug 4, 1998·International Journal of Cardiology·T HayashiK Kawamura
Mar 7, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J J KrüseJ Wondergem
Jul 1, 1997·Journal of the American College of Cardiology·M M MarijianowskiA E Becker
Apr 11, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B A BrucknerG Torre-Amione
May 1, 1998·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·M L Coker, F G Spinale
Mar 18, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Y T ChiuR Chu
Apr 21, 2004·Current Opinion in Cardiology·Cynthia K WallaceGuillermo Torre-Amione
Feb 8, 2011·Journal of Cardiovascular Pharmacology·Filomena G Ottaviano, Karen O Yee
Feb 1, 1993·British Journal of Obstetrics and Gynaecology·M SavvasJ Studd
Jul 31, 2002·Congestive Heart Failure·R D Patten, M A Konstam
Mar 27, 1995·Annals of the New York Academy of Sciences·R P ButtJ E Bishop
Jan 9, 2010·Circulation Research·Rahul Kakkar, Richard T Lee
Apr 18, 2002·European Journal of Heart Failure·Philipp StawowyKristof Graf
Nov 16, 2010·Canadian Journal of Physiology and Pharmacology·Jianhua ZhangRen Zhao
Aug 10, 2005·European Journal of Heart Failure·Mamoru SatohKatsuhiko Hiramori
Apr 20, 2007·International Journal of Cardiology·Pekka TimonenKeijo Peuhkurinen
Jul 19, 2015·Interactive Cardiovascular and Thoracic Surgery·Yoko MizunoNaomasa Kawaguchi
Feb 19, 2011·Journal of the American College of Cardiology·Nathan MewtonJoão A C Lima
Sep 5, 2009·Journal of Molecular and Cellular Cardiology·J YanniH Dobrzynski
Jul 9, 2016·International Journal of Cardiology·Laura Louzao-MartinezCaroline Cheng
May 29, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Christopher N ToepferMichael A Ferenczi
Feb 18, 2010·Circulation·Rajiv R ChaturvediJonathan C Kentish

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