ENHANCED DISEASE RESISTANCE4 associates with CLATHRIN HEAVY CHAIN2 and modulates plant immunity by regulating relocation of EDR1 in Arabidopsis

The Plant Cell
Guangheng WuDingzhong Tang

Abstract

Obligate biotrophs, such as the powdery mildew pathogens, deliver effectors to the host cell and obtain nutrients from the infection site. The interface between the plant host and the biotrophic pathogen thus represents a major battleground for plant-pathogen interactions. Increasing evidence shows that cellular trafficking plays an important role in plant immunity. Here, we report that Arabidopsis thaliana ENHANCED DISEASE RESISTANCE4 (EDR4) plays a negative role in resistance to powdery mildew and that the enhanced disease resistance in edr4 mutants requires salicylic acid signaling. EDR4 mainly localizes to the plasma membrane and endosomal compartments. Genetic analyses show that EDR4 and EDR1 function in the same genetic pathway. EDR1 and EDR4 accumulate at the penetration site of powdery mildew infection, and EDR4 physically interacts with EDR1, recruiting EDR1 to the fungal penetration site. In addition, EDR4 interacts with CLATHRIN HEAVY CHAIN2 (CHC2), and edr4 mutants show reduced endocytosis rates. Taken together, our data indicate that EDR4 associates with CHC2 and modulates plant immunity by regulating the relocation of EDR1 in Arabidopsis.

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Citations

Sep 9, 2015·Journal of Integrative Plant Biology·Wen-Ming WangShun-Yuan Xiao
Sep 22, 2016·Proceedings of the National Academy of Sciences of the United States of America·Malick MbengueSilke Robatzek
May 16, 2017·The Plant Journal : for Cell and Molecular Biology·Yunwei ZhangDingzhong Tang
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May 17, 2017·Proceedings of the National Academy of Sciences of the United States of America·Qiujing ShenDingzhong Tang
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Sep 16, 2017·Current Opinion in Plant Biology·Erica D LaMontagne, Antje Heese
Aug 17, 2021·The Plant Journal : for Cell and Molecular Biology·Wei WangDingzhong Tang

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