PMID: 16501718Feb 28, 2006Paper

Enhanced disease surveillance through private health care sector cooperation in Karachi, Pakistan: experience from a vaccine trial

Bulletin of the World Health Organization
M Imran KhanZulfiqar A Bhutta

Abstract

In research projects such as vaccine trials, accurate and complete surveillance of all outcomes of interest is critical. In less developed countries where the private sector is the major health-care provider, the private sector must be included in surveillance systems in order to capture all disease of interest. This, however, poses enormous challenges in practice. The process and outcome of recruiting private practice clinics for surveillance in a vaccine trial are described. The project started in January 2002 in two urban squatter settlements of Karachi, Pakistan. At the suggestion of private practitioners, a phlebotomy team was formed to provide support for disease surveillance. Children who had a reported history of fever for more than three days were enrolled for a diagnosis. Between May 2003 and April 2004, 5540 children younger than 16 years with fever for three days or more were enrolled in the study. Of the children, 1312 (24%) were seen first by private practitioners; the remainder presented directly to study centres. In total, 5329 blood samples were obtained for microbiology. The annual incidence of Salmonella typhi diagnosed by blood culture was 407 (95% confidence interval (95% CI), 368-448) per 100 000/year and ...Continue Reading

Citations

Nov 13, 2012·PloS One·Francesca MicoliLaura B Martin
Aug 22, 2013·Health Policy and Planning·Nothemba Kula, Robert J Fryatt
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alfred PachFlorian Marks
Mar 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christian S MarchelloJohn A Crump
Nov 1, 2016·Expert Review of Vaccines·Stephen K ObaroEric Daniel Mintz

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