Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

Science
C L YuR Jove

Abstract

Cytokines and growth factors induce tyrosine phosphorylation of signal transducers and activators of transcription (STATs) that directly activate gene expression. Cells stably transformed by the Src oncogene tyrosine kinase were examined for STAT protein activation. Assays of electrophoretic mobility, DNA-binding specificity, and antigenicity indicated that Stat3 or a closely related STAT family member was constitutively activated by the Src oncoprotein. Induction of this DNA-binding activity was accompanied by tyrosine phosphorylation of Stat3 and correlated with Src transformation. These findings demonstrate that Src can activate STAT signaling pathways and raise the possibility that Stat3 contributes to oncogenesis by Src.

References

Aug 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·X Y FuJ E Darnell
Jan 1, 1987·Annual Review of Cell Biology·R Jove, H Hanafusa
Feb 24, 1995·The Journal of Biological Chemistry·G S CampbellC Carter-Su
May 1, 1994·Trends in Biochemical Sciences·J N IhleO Silvennoinen
Sep 16, 1994·Science·J HouS L McKnight

❮ Previous
Next ❯

Citations

May 18, 2011·Archives of Otolaryngology--head & Neck Surgery·Waleed M AbuzeidThomas E Carey
Jan 1, 1996·Developmental Genetics·L A MegeneyM A Rudnicki
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y WangH Baumann
May 3, 2002·The Prostate·Rajiv DhirAllen C Gao
Jul 14, 1998·Journal of Biomedical Science·R Garcia, R Jove
May 10, 2001·International Journal of Hematology·W J Leonard
Sep 5, 2003·International Journal of Hematology·Hideaki IshikawaMichio M Kawano
Oct 9, 2007·Journal of Cancer Research and Clinical Oncology·Mikio TomidaMasafumi Kurosumi
Jun 30, 2005·Cancer Metastasis Reviews·Marcin KortylewskiHua Yu
Sep 23, 2010·Journal of Clinical Immunology·Attila KumánovicsHarry R Hill
Oct 26, 2012·Journal of Neuro-oncology·Alfred P SeeMichael Lim
Mar 26, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hai-bo ShenJuan Qi
Nov 1, 1995·Cellular Signalling·D S Finbloom, A C Larner
Sep 1, 1996·Trends in Cell Biology·J BriscoeM Müller
Apr 28, 2004·Cytokine & Growth Factor Reviews·Dhananjaya V Kalvakolanu
Nov 12, 2002·Cellular Immunology·P K Epling-BurnetteSheng Wei
May 5, 2001·Leukemia Research·R L Ilaria
Apr 27, 2000·Molecular Immunology·K Imada, W J Leonard
Jul 16, 2003·Cancer Letters·Jean M NussbaumShobha Gunnery
Oct 15, 2003·Free Radical Biology & Medicine·Yi-Zhe WangJames C Bonner
Jun 25, 1998·Current Opinion in Immunology·K D LiuM A Goldsmith
Oct 1, 1996·Current Opinion in Genetics & Development·S Watanabe, K i Arai
Sep 29, 1999·Trends in Biochemical Sciences·T NakaT Kishimoto
May 19, 2000·Cytokine & Growth Factor Reviews·K Takeda, S Akira
Jun 10, 1998·Cytokine & Growth Factor Reviews·J X Lin, W J Leonard
Jan 14, 2011·ACS Chemical Biology·Ralf BuettnerJohn C Williams
Jun 5, 2001·Nature Reviews. Molecular Cell Biology·G S Martin
Mar 10, 2012·Cell Death and Differentiation·M DemariaV Poli
Jan 30, 2008·Cell Research·Khandaker Al Zaid Siddiquee, James Turkson
Feb 18, 2004·Nature Reviews. Cancer·Hua Yu, Richard Jove
Jun 2, 2004·Nature Reviews. Cancer·Timothy J Yeatman
May 21, 2005·Nature Reviews. Cancer·Martin E Gleave, Brett P Monia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.