Enhanced Drug Delivery to the Skin Using Liposomes

Plastic and Reconstructive Surgery. Global Open
Gert BlueschkeBruce Klitzman

Abstract

Enhancing drug delivery to the skin has importance in many therapeutic strategies. In particular, the outcome in vascularized composite allotransplantation mainly depends on systemic immunosuppression to prevent and treat episodes of transplant rejection. However, the side effects of systemic immunosuppression may introduce substantial risk to the patient and are weighed against the expected benefits. Successful enhancement of delivery of immunosuppressive agents to the most immunogenic tissues would allow for a reduction in systemic doses, thereby minimizing side effects. Nanoparticle-assisted transport by low temperature-sensitive liposomes (LTSLs) has shown some benefit in anticancer therapy. Our goal was to test whether delivery of a marker agent to the skin could be selectively enhanced. In an in vivo model, LTSLs containing doxorubicin (dox) as a marker were administered intravenously to rats that were exposed locally to mild hyperthermia. Skin samples of the hyperthermia treated hind limb were compared with skin of the contralateral normothermia hind limb. Tissue content of dox was quantified both via high-performance liquid chromatography and via histology in skin and liver. The concentration of dox in hyperthermia-trea...Continue Reading

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Citations

Jan 13, 2019·International Journal of Molecular Sciences·Claudia CampanellaStefano Fais
Oct 30, 2018·Frontiers in Pharmacology·Leslie StradiotLeo A van Grunsven
Nov 25, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Ali-Farid SafiBohdan Pomahač

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