Enhanced effect of gap junction uncouplers on macroscopic electrical properties of reperfused myocardium

The Journal of Physiology
Antonio Rodríguez-SinovasJordi Soler-Soler

Abstract

Transient inhibition of gap junction (GJ)-mediated communication with heptanol during myocardial reperfusion limits infarct size. However, inhibition of cell coupling in normal myocardium may be arrhythmogenic. The purpose of this study was to test the hypothesis that the consequences of GJ inhibition may be magnified in reperfused myocardium compared with normal tissue, thus allowing the inhibition of GJs in reperfused tissue while only minimally modifying overall macroscopic cell coupling in normal myocardium. Concentration-response curves were defined for the effects of heptanol, 18alpha-glycyrrhetinic acid, halothane, and palmitoleic acid on conduction velocity, tissue electrical impedance, developed tension and lactate dehydrogenase (LDH) release in normoxically perfused rat hearts (n= 17). Concentrations lacking significant effects on tissue impedance were added during the initial 15 min of reperfusion in hearts submitted to 60 min (n= 43) or 30 min (n= 35) of ischaemia. These concentrations markedly increased myocardial electrical impedance (resistivity and phase angle) in myocardium reperfused after either 30 or 60 min of ischaemia, and reduced reperfusion-induced LDH release after 1 h of ischaemia by 83.6, 57.9, 51.7 a...Continue Reading

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Citations

May 29, 2007·Heart Failure Reviews·Antonio Rodríguez-SinovasDavid Garcia-Dorado
Jun 29, 2010·Antioxidants & Redox Signaling·Javier InserteDavid Garcia-Dorado
May 23, 2009·Cardiovascular Research·Elisabet Miro-CasasDavid Garcia-Dorado
Apr 20, 2012·Cardiovascular Research·Olivier MorelMichel Ovize
Apr 30, 2014·Revista Española De Cardiología·David Garcia-DoradoJavier Inserte
Mar 19, 2014·Cardiovascular Research·Sandrine MorelBrenda R Kwak
Apr 22, 2014·Brain Research Bulletin·Jan KonopackiPaulina Kłos-Wojtczak
Apr 10, 2010·Journal of Biomedicine & Biotechnology·Takahiko ShiinaYasutake Shimizu
Apr 15, 2006·Cell Communication & Adhesion·Wattamon SrisakuldeeElissavet Kardami
Feb 17, 2010·The Journal of Physiology·Antonio Rodríguez-SinovasDavid García-Dorado
Jun 30, 2009·Journal of Ethnopharmacology·Yimei DuYuhua Liao
Sep 13, 2006·The European Journal of Neuroscience·Henryk GołebiewskiJan Konopacki
Apr 30, 2013·IEEE Transactions on Bio-medical Engineering·Andrew E Pollard, Roger C Barr
Aug 16, 2011·Biochimica Et Biophysica Acta·Antonio Rodríguez-SinovasDavid Garcia-Dorado
Sep 27, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Antonio Rodríguez-SinovasJordi Soler-Soler
Sep 29, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jose A SánchezDavid García-Dorado
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Kerstin BoenglerRainer Schulz
Dec 19, 2019·Acta Cirúrgica Brasileira·Alexandre Maximiliano TrevisanLuiz Augusto Carneiro D'Albuquerque
Apr 28, 2007·Progress in Biophysics and Molecular Biology·Antonio Rodríguez-SinovasDavid García-Dorado
May 1, 2021·International Journal of Molecular Sciences·Antonio Rodríguez-SinovasIgnacio Ferreira-González

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