PMID: 8583372Aug 1, 1995Paper

Enhanced effectiveness of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in combination with garlic oil against experimental hepatic injury in rats and mice

The Journal of Pharmacy and Pharmacology
Sang Geon KimK H Jung

Abstract

The present study was designed to evaluate the effects of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (PMC) in combination with garlic oil against chemical-induced hepatic injury in rats and mice. Rats insulted with carbon tetrachloride were concomitantly treated with PMC and/or garlic oil (50 and 100 mg kg-1, respectively) for four weeks. Whereas treatment of animals with garlic oil alone was ineffective in suppressing carbon tetrachloride-induced hepatotoxicity, administration of PMC in combination with garlic oil more effectively protected the liver against the carbon tetrachloride-induced insult than PMC alone, as monitored by serum aminotransferase activity. Hepatoprotective effects of the formulation were further supported by the changes in the numbers of Kupffer cells and dead hepatocytes. Although prior treatment of rats with PMC for three days failed to protect hepatotoxicity elicited by allyl alcohol, the formulation of PMC and garlic oil was capable of blocking allyl alcohol-induced hepatotoxicity by approximately 40%. To further examine the effect of the agents on lipid metabolism in the liver, hepatic triglycerides and cholesterol contents were assessed in mice after a diet contai...Continue Reading

References

Jul 1, 1992·Toxicology and Applied Pharmacology·J M PrzybockiF C Kauffman
Apr 1, 1991·Toxicology and Applied Pharmacology·J F BradyJ M Gapac
Dec 31, 1981·Biochemical and Biophysical Research Communications·K T LiuP Lesca
May 16, 1994·Biochemical and Biophysical Research Communications·S G KimN D Kim
Apr 1, 1993·Toxicology and Applied Pharmacology·M J EdwardsR G Thurman

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Citations

Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·C K KimZ G Gao
Aug 10, 2013·Microbiological Research·S VijayanandrajR Velazhahan
Dec 8, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hee E KangMyung G Lee
Feb 3, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Nassr-Allah H Abdel-Hameid

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