Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

Cell Death and Differentiation
L TianJ E Coligan

Abstract

Homeostasis requires the immunologically silent clearance of apoptotic cells before they become pro-inflammatory necrotic cells. CD300f (CLM-1) is a phosphatidylserine receptor known to positively regulate efferocytosis by macrophages, and CD300f gene-deficient mice are predisposed to develop a lupus-like disease. Here we show that, in contrast to CD300f function in macrophages, its expression inhibits efferocytosis by DC, and its deficiency leads to enhanced antigen processing and T-cell priming by these DC. The consequences are the expansion of memory T cells and increased ANA levels in aged CD300f-deficient mice, which predispose CD300f-deficient mice to develop an overt autoimmune disease when exposed to an overload of apoptotic cells, or an exacerbated autoimmunity when combined with FcγRIIB deficiency. Thus, our data demonstrates that CD300f helps to maintain immune homeostasis by promoting macrophage clearance of self-antigens, while conversely inhibiting DC uptake and presentation of self-antigens.

References

Jun 1, 1989·European Journal of Immunology·A LernerR A Miller
Dec 6, 1997·Nature·R E VollI Girkontaite
Jul 22, 1998·The Journal of Experimental Medicine·D MevorachK B Elkon
Dec 23, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J E WitherL A Brennan
Feb 9, 2000·The Journal of Experimental Medicine·R M SteinmanK Inaba
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L M ShlapatskaS P Sidorenko
May 11, 2001·Nature·R S ScottG K Matsushima
May 10, 2002·Nature·Rikinari HanayamaShigekazu Nagata
May 30, 2002·Nature Reviews. Immunology·Flavius Martin, John F Kearney
Oct 23, 2002·The Journal of Experimental Medicine·Kang LiuRalph M Steinman
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Laura HaynesSusan L Swain
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dong-Hui ChungMichael R Daws
May 25, 2004·Science·Rikinari HanayamaShigekazu Nagata
Mar 18, 2005·Annual Review of Immunology·E Sergio Trombetta, Ira Mellman
Aug 30, 2005·Nature Immunology·Romain RoncagalliAndré Veillette
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicola CalvaniHanno B Richards
Jan 25, 2006·Autoimmunity Reviews·Martina Prelog
Mar 15, 2006·Trends in Cell Biology·Yi WuRaymond B Birge
Oct 27, 2006·The FEBS Journal·Sassan Hafizi, Björn Dahlbäck
Oct 27, 2007·Cell Death and Differentiation·S-Y ParkI-S Kim
Dec 3, 2008·The Journal of Experimental Medicine·Pui Y LeeWestley H Reeves
Dec 10, 2008·The Journal of Experimental Medicine·Vilma UrbonaviciuteReinhard E Voll
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chun-Hong QiuMasato Tanaka
Apr 11, 2009·Trends in Immunology·Georgina J ClarkDerek N J Hart
Dec 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ricardo A ChaurioUdo S Gaipl
Dec 30, 2009·The Journal of Experimental Medicine·Hongkang XiMenno van Lookeren Campagne
Mar 10, 2010·Cell·Shigekazu NagataKohki Kawane
Jun 30, 2010·The Journal of Cell Biology·Michael R Elliott, Kodi S Ravichandran
Sep 2, 2010·The Journal of Experimental Medicine·Kodi S Ravichandran
Oct 21, 2010·The Journal of Biological Chemistry·Agueda Martínez-BarriocanalJoan Sayós
Jul 12, 2011·Inflammatory Bowel Diseases·Robert BurakoffChoong-Chin Liew
Aug 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seung-Chul ChoiJohn E Coligan
Sep 14, 2011·Annual Review of Pathology·Ronald S FlannaganSergio Grinstein
Dec 14, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaobin TangJohn E Coligan

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Citations

Jan 19, 2018·Journal of Leukocyte Biology·Perri RozenbergAriel Munitz
May 7, 2020·Cell Communication and Signaling : CCS·Yunxiang ZhouAnwen Shao
May 27, 2016·The Journal of Microbiology·Jae-Min Song
Jan 27, 2019·Apoptosis : an International Journal on Programmed Cell Death·Lanzhou Jiang, Ivan K H Poon
Mar 8, 2018·Current Protocols in Immunology·Oliver H VossJohn E Coligan
Mar 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Natalia LagoHugo Peluffo
Apr 18, 2017·The Journal of Clinical Investigation·Ha-Na LeeKonrad Krzewski
Feb 7, 2021·International Immunopharmacology·Yue CaoXiaohong Tian
Apr 16, 2021·Nature Communications·Nicoletta CaronniFederica Benvenuti
May 28, 2021·EMBO Reports·Shannon M Kelley, Kodi S Ravichandran

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