Enhanced efficacy and drug delivery with lipid coated mesoporous silica nanoparticles in cancer therapy.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Muhammad Umair AminJana Brüßler

Abstract

The exposure of cancer cells to subtherapeutic drug concentrations results in multidrug resistance (MDR). The uniqueness of mesoporous silica nanoparticles (MSNPs) with larger surface area for higher drug loading can solve the issue by delivering higher amounts of chemotherapeutics to the cancer cells. However, premature drug release and lower biocompatibility remain challenging. Lipid coating of MSNPs at the same time, can enhance the stability and biocompatibility of nanocarriers. Furthermore, the lipid coating can reduce the systemic drug release and deliver higher amounts to the tumor site. Herein, lipid coated MSNPs were prepared by utilizing cationic liposomes and further investigations were made. Our studies have shown the higher entrapment of doxorubicin (Dox) to MSNPs due to availability of porous structure. Lipid coating could provide a barrier to sustain the release of drug along with reduced premature leakage. In addition, the biocompatibility and enhanced interaction of cationic liposomes to cell membranes resulted in better cellular uptake. Lipid coated silica nanoparticles have shown higher cellular toxicity as compared to non-lipid coated particles. The increase in cytotoxicity with time supports the hypothesis ...Continue Reading

References

Jan 29, 2009·Journal of the American Chemical Society·Juewen LiuC Jeffrey Brinker
Jul 4, 2009·Angewandte Chemie·Andrea BernardosPedro Amorós
Jun 22, 2010·Biomaterials·Jens SchäferAchim Aigner
Aug 7, 2010·Small·Juan L Vivero-EscotoVictor S-Y Lin
Jan 11, 2011·Journal of the American Chemical Society·Chun-Ling ZhuXiao-Ru Wang
Mar 2, 2012·Advanced Materials·Fangqiong TangDong Chen
Mar 23, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ellen C DenglerErin D Milligan
May 28, 2013·Chemical Reviews·Valentin Valtchev, Lubomira Tosheva
Sep 11, 2013·Journal of Tissue Engineering·Sooyeon KwonWojciech Chrzanowski
Mar 19, 2014·Colloids and Surfaces. B, Biointerfaces·Jana BrüsslerUdo Bakowsky
May 27, 2015·Chemical Reviews·Bhushan S PattniVladimir P Torchilin
Aug 11, 2015·International Journal of Pharmaceutical Investigation·Charu BhartiNeha Gulati
Jun 22, 2016·Soft Matter·Christopher JanichChristian Wölk
Jul 19, 2016·Expert Opinion on Drug Delivery·Noura H Abd Ellah, Sara A Abouelmagd
Feb 9, 2017·International Journal of Biological Macromolecules·Min ZhangBingbing Jiang
Mar 7, 2017·Journal of the American Chemical Society·Alden M ClemmentsChristopher C Landry
Mar 10, 2017·Drug Development and Industrial Pharmacy·Haohuan LiTianyuan Ci
Jun 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Yongju HeHui Xu
Aug 30, 2017·Chemical Society Reviews·Jia WenShiguo Sun
Jan 18, 2018·Nanomedicine : Nanotechnology, Biology, and Medicine·Maria A Gonzalez PorrasCarlos B Mantilla
Dec 28, 2018·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Imran TariqUdo Bakowsky
Jan 11, 2019·Journal of Functional Biomaterials·Eleonora CalzoniCarla Emiliani
Jun 15, 2019·ACS Applied Materials & Interfaces·Qi YanYanjun Zhao
Oct 19, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Muhammad Yasir AliUdo Bakowsky
Dec 18, 2019·International Journal of Pharmaceutics·Muhammad Yasir AliUdo Bakowsky
Mar 11, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sajid AliUdo Bakowsky

❮ Previous
Next ❯

Citations

Jul 3, 2021·International Journal of Molecular Sciences·Ruslan KashapovOleg Sinyashin
Jul 30, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Dagmara Hoc, Dorota Haznar-Garbacz
Aug 31, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wei ZhangLu Xu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.