Enhanced Efflux Pump Activity in Old Candida glabrata Cells

Antimicrobial Agents and Chemotherapy
Somanon Bhattacharya, Bettina C Fries

Abstract

We investigated the effect of replicative aging on antifungal resistance in Candida glabrata Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.

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Citations

Jun 13, 2020·Antibiotics·Somanon BhattacharyaBettina C Fries
Dec 31, 2020·Journal of Fungi·Somanon BhattacharyaBettina C Fries
Jul 3, 2021·Journal of Fungi·Somanon BhattacharyaBettina C Fries
Aug 27, 2021·Journal of Fungi·Yahaya HassanLeslie Thian Lung Than

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