PMID: 11903397Mar 21, 2002Paper

Enhanced endothelial activation in diabetic patients with unstable angina and non-Q-wave myocardial infarction

Diabetic Medicine : a Journal of the British Diabetic Association
N T MulvihillM Walsh

Abstract

Diabetes mellitus (DM) is associated with chronic endothelial dysfunction. Diabetic patients presenting with acute coronary syndromes have a worse prognosis than non-diabetics. An acute inflammatory reaction at the site of coronary plaque rupture and increased expression of surface and soluble cellular adhesion molecules (CAMs) are pathological features of acute coronary syndromes. We set out to characterize the expression of soluble CAMs in patients with and without diabetes presenting with unstable angina (UA) and non Q-wave myocardial infarction (NQMI). Patients presenting with UA and NQMI had serum samples taken on presentation, after 72 h and then 3, 6 and 12 months after discharge. Levels of soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin and P-selectin were measured using an ELISA technique. We studied 15 diabetic patients and 15 age- and sex-matched non-diabetic patients presenting with either UA or NQMI. Levels of soluble E-selectin were elevated in the diabetic patients in comparison with the non-diabetic patients at all measured time points: 74 +/- 10 ng/ml vs. 47 +/- 3 ng/ml, P < 0.03 at t = 0 h, 55 +/- 5 ng/ml vs. 38 +/- 2 ng/ml, P < 0.02 at t = 72 h. Howev...Continue Reading

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Citations

May 8, 2002·Diabetes/metabolism Research and Reviews
Nov 13, 2003·Atherosclerosis·Stefan BlankenbergLaurence Tiret
Nov 1, 2011·Cardiovascular Diabetology·Chang Seong KimUNKNOWN Korea Acute Myocardial Infarction Registry Investigators
Aug 21, 2013·Journal of the American College of Cardiology·Dimitris TousoulisChristodoulos Stefanadis
Apr 28, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Ju Han KimUNKNOWN Korea Acute Myocardial Infarction-National Institutes of Health Registry Investigators
Jun 28, 2014·The Cochrane Database of Systematic Reviews·Carlos A Andrade-CastellanosKirk Magee
Apr 29, 2021·Yonsei Medical Journal·Xiongyi HanUNKNOWN Other KAMIR-NIH Registry Investigators

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