Enhanced endothelial nitric oxide activity contributes to the reduced responsiveness of vascular alpha1-adrenoceptors following aortic barodenervation

European Journal of Pharmacology
M M el-MasA G Abdel-Galil

Abstract

We have recently shown that short-term aortic barodenervation diminishes constrictor responses to activation of alpha1-adrenoceptors in rat aortic smooth muscle. This study investigated the potential role of vascular endothelium and its derived vasoactive substances, nitric oxide and prostaglandins, in the reduced alpha1-adrenoceptor responsiveness after aortic barodenervation. Exposure of isolated aortic rings from aortic barodenervated and sham-operated rats 48 h after surgery to cumulative addition of phenylephrine (alpha1-adrenoceptor agonist, 3 x 10(-8) - 1 X 10(-4) M) resulted in concentration-related contractions that were significantly (P < 0.05) smaller in rings of denervated rats. Removal of the endothelium increased phenylephrine-mediated contractions in rings obtained from aortic barodenervated rats to near sham-operated levels as demonstrated by the similar contractile responses and slopes of the regression lines of the concentration-response curves. Pretreatment with indomethacin (cyclooxygenase inhibitor, 1 x 10[-5] M) had no effect on contractile responses to phenylephrine in rings from both groups of rats. In contrast, N(G)-nitro-L-arginine (nitric oxide synthase inhibitor, 3 x 10[-5] M) elevated basal vascular...Continue Reading

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Citations

Jul 25, 2003·Toxicology and Applied Pharmacology·Luiz Borges Bispo Da Silva, Sandra Cordellini
Aug 28, 2003·Clinical and Experimental Hypertension : CHE·Mahmoud M El-MasS Jamal Mustafa
Apr 16, 2004·Journal of Cardiovascular Pharmacology·Mahmoud M El-MasFouad M Sharabi
Aug 9, 2001·International Journal of Impotence Research·C J WingardT M Mills
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Mahmoud M El-MasFouad M Sharabi
Sep 25, 2002·Canadian Journal of Physiology and Pharmacology·Mahmoud M El-MasFouad M Sharabi
Aug 3, 2013·Alcoholism, Clinical and Experimental Research·Mahmoud M El-MasAbdel A Abdel-Rahman

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