Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis.

Molecular and Cellular Biology
R ZirngiblPeter Greer

Abstract

The fps/fes proto-oncogene encodes a cytoplasmic protein tyrosine kinase implicated in growth factor and cytokine receptor signaling and thought to be essential for the survival and terminal differentiation of myeloid progenitors. Fps/Fes-null mice were healthy and fertile, displayed slightly reduced numbers of bone marrow myeloid progenitors and circulating mature myeloid cells, and were more sensitive to lipopolysaccharide (LPS). These phenotypes were rescued using a fps/fes transgene. This confirmed that Fps/Fes is involved in, but not required for, myelopoiesis and that it plays a role in regulating the innate immune response. Bone marrow-derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony-stimulating factor-, interleukin 6 (IL-6)-, or IL-3-induced activation of signal transducer and activator of transcription 3 (Stat3) and Stat5A or LPS-induced degradation of I kappa B or activation of p38, Jnk, Erk, or Akt.

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Citations

Dec 10, 2003·Experimental Hematology·Waheed SangrarPeter A Greer
Aug 7, 2003·Experimental Hematology·Yotis A SenisPeter A Greer
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·Y A SenisP A Greer
Jun 13, 2014·Open Biology·Mirko PesceAntonia Patruno
Apr 22, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Kushal Y BhaktaCaraciolo J Fernandes
Jul 28, 2011·Experimental Animals·Adriana StrzalkowskaElzbieta Wirth-Dzieciolowska
May 4, 2007·International Journal of Laboratory Hematology·I AkalinA Tukun
May 8, 2002·Nature Reviews. Molecular Cell Biology·Peter Greer
Mar 19, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Daisuke AkiAkihiko Yoshimura
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donna-Marie McCaffertyPeter A Greer
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bin WangJohn W Schrader
May 4, 2017·The Journal of Clinical Investigation·Michael OlvedyJean-Christophe Marine
May 4, 2005·Cancer Research·Waheed SangrarPeter A Greer
Oct 27, 2004·Experimental Hematology·Waheed SangrarPeter A Greer

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