Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Zenab AttariShaila Lewis

Abstract

The purpose of this study was to develop nanosuspension based on combinative technology to enhance the intestinal absorption of Olmesartan medoxomil (OLM), a potent antihypertensive agent with limited oral bioavailability. Two combinative approaches were employed and then characterized. In vitro intestinal absorption of OLM nanosuspension and plain OLM was studied using non-everted rat intestinal sac model. Optimal OLM nanosuspension was prepared by a combination of ball milling and probe sonication using stabilizer, Poloxamer 407. The formula exhibited particle size of 469.9 nm and zeta potential of -19.1 mV, which was subjected to ex vivo studies. The flux and apparent permeability coefficient in intestine from OLM nanosuspension was higher than the plain drug, thereby suggesting better drug delivery.

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Citations

Aug 30, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Róbert LehockýFrantišek Štěpánek
Nov 7, 2016·Regulatory Toxicology and Pharmacology : RTP·Bapi GorainTapan Kumar Pal
Jan 25, 2017·Drug Delivery and Translational Research·Sanyog JainChander Parkash Dora
Aug 6, 2019·Advanced Pharmaceutical Bulletin·Revathy SreedharSabitha Mangalathillam
Apr 7, 2020·Drug Development and Industrial Pharmacy·Fahima M HashemAbdelsabour A A Hassan
Apr 16, 2020·Drug Development and Industrial Pharmacy·Sachin BhusariAvinash Chaudhary
May 24, 2017·AAPS PharmSciTech·Sonia GeraSunitha Sampathi
Dec 22, 2021·Pharmaceutical Development and Technology·Sıla Gülbağ PınarNevin Çelebi

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Methods Mentioned

BETA
Differential Scanning Calorimetry

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