PMID: 8594542Oct 1, 1995Paper

Enhanced excitatory junction potentials in mesenteric arteries from spontaneously hypertensive rats

Pflügers Archiv : European journal of physiology
J A Brock, D F Van Helden

Abstract

Excitatory junction potentials (EJPs) were examined using intracellular recording techniques in mesenteric arteries isolated from 12- to 15-week-old spontaneously hypertensive (SHR), Wistar Kyoto (WKY) and Sprague Dawley (SD) rats. The amplitudes of EJPs evoked by single supramaximal stimuli were larger in arteries from SHRs (12.9 +/- 0.7 mV, n = 16) than in arteries from either WKYs (5.2 +/- 0.5 mV, n = 24) or SDs (8.6 +/- 0.8 mV, n = 15). The time constant of decay of EJPs did not differ significantly, suggesting that the passive electrical properties of the vascular smooth muscle are similar in the three rat strains. Spontaneous EJPs recorded in tissues from SHRs and WKYs had similar amplitude frequency distributions, suggesting that the quantal size is also similar between strains. In some arteries from SHRs, EJPs evoked by single stimuli triggered muscle action potentials (MAPs). Visible constriction only occurred following a MAP. In tissues from all three strains, summation of EJPs triggered MAPs. As EJPs are generated by the sympathetic co-transmitter adenosine 5'-triphosphate (ATP), the findings of the present study indicate that purinergic transmission is enhanced in mesenteric arteries from SHRs, probably as a result ...Continue Reading

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Citations

Mar 28, 2008·Purinergic Signalling·David Erlinge, Geoffrey Burnstock
Jun 28, 2000·Journal of the Autonomic Nervous System·P Sneddon
Apr 3, 1999·Journal of the Autonomic Nervous System·M A HansenM R Bennett
Dec 1, 1996·Journal of Autonomic Pharmacology·G Burnstock
Jun 22, 2011·Acta Physiologica·E Storkebaum, P Carmeliet
Nov 29, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Juliano Quintella Dantas RodriguesAron Jurkiewicz
Feb 25, 2014·Pharmacology & Therapeutics·Janette M Bulloch, Craig J Daly
May 18, 2011·The Journal of Physiology·Rebecca E Haddock, Caryl E Hill
May 19, 2007·The Journal of Physiology·Nicole M RummeryWilliam R Dunn
Jul 2, 2009·Autonomic & Autacoid Pharmacology·G Burnstock
Jun 3, 2014·Pharmacology & Therapeutics·Violeta N Mutafova-Yambolieva, Leonie Durnin
Jun 6, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yukiko Nomura, Masahisa Asano
May 26, 2015·Autonomic Neuroscience : Basic & Clinical·Vera Ralevic, William R Dunn
Jan 13, 2015·Autonomic Neuroscience : Basic & Clinical·Jody L GreaneyWilliam B Farquhar
Feb 23, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Juliano Q D RodriguesRosely O Godinho
Jan 7, 2017·Circulation Research·Geoffrey Burnstock
Mar 22, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Shaun L SandowCaryl E Hill
Mar 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Geoffrey Burnstock
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Sep 14, 2019·Journal of Cardiovascular Pharmacology·Juliano Quintella Dantas RodriguesAron Jurkiewicz
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock
Jul 19, 2020·International Journal of Molecular Sciences·Bruno Bragança, Paulo Correia-de-Sá
Feb 27, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hui XuJames J Galligan
Aug 3, 2021·Autonomic Neuroscience : Basic & Clinical·Charles Kennedy

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