Enhanced expression of 14-3-3 proteins in reactive astrocytes in Creutzfeldt-Jakob disease brains

Acta Neuropathologica
Yasuhiro KawamotoH Budka

Abstract

14-3-3 proteins have been reported to be detected specifically in the cerebrospinal fluid (CSF) from patients with Creutzfeldt-Jakob disease (CJD). To elucidate the role of 14-3-3 proteins in patients with CJD, we performed immunohistochemical studies on 14-3-3 proteins in autopsied brains from five patients with sporadic CJD (sCJD), three patients with Alzheimer's disease (AD), and seven normal control subjects. Formalin-fixed, paraffin-embedded sections from all cases were immunostained with several types of specific anti-14-3-3 antibodies. In the normal control brains, 14-3-3 immunoreactivity was localized mainly in the neuronal somata and processes; in contrast, glial cells showed no or faint immunoreactivity. In the brains from the patients with AD, 14-3-3 immunoreactivity was observed in the surviving neurons as well as some neurofibrillary tangles. In the brains from the patients with sCJD, 14-3-3 immunoreactivity was well preserved in the remaining neurons. Furthermore, the glial cells, especially the reactive astrocytes, were intensely immunostained in the brains affected by sCJD. Our findings suggest that 14-3-3 proteins may be up-regulated in the glial cells, particularly in reactive astrocytes, and that the enhanced...Continue Reading

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Citations

Sep 23, 2006·BMC Neurology·Constanze Boesenberg-GrosseInga Zerr
Jan 21, 2006·Stroke; a Journal of Cerebral Circulation·Yasuhiro KawamotoHerbert Budka
Feb 7, 2007·Journal of Neuropathology and Experimental Neurology·Giuseppe Di FedeFabrizio Tagliavini
Nov 17, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Young Kyoung JangSang Won Seo
Nov 5, 2020·Scientific Reports·Daniela GerovskaMarcos J Araúzo-Bravo

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