PMID: 8587458Jan 1, 1995Paper

Enhanced expression of endothelin-1 gene may cause blood pressure-independent vascular hypertrophy

Journal of Cardiovascular Pharmacology
E L SchiffrinR M Touyz

Abstract

Endothelin-1 (ET-1) has hypertrophic and mitogenic properties. Enhanced ET-1 gene expression in blood vessels of deoxycorticosterone acetate (DOCA)/salt hypertensive rats and DOCA/salt spontaneously hypertensive rats (SHRs) was previously demonstrated. In this study, the effect on ET-1 gene expression in blood vessels and on vascular hypertrophy of the development of hypertension of DOCA/salt hypertensive rats, and that of salt and DOCA, were investigated in Sprague-Dawley rats and in SHRs. Increased abundance of ET-1 mRNA and a greater content of immunoreactive ET-1 were found with progression of hypertension in the aorta and the mesenteric arterial bed only in DOCA/salt hypertensive rats and in DOCA/salt SHRs. Vascular expression of ET-1 was not enhanced in DOCA- or salt-treated rats, even when blood pressure rose to a mean systolic pressure of 210 mm Hg. The media thickness and the media cross-sectional area of mesenteric resistance arteries of all groups of rats, including SHRs and Wistar-Kyoto (WKY) rats, exhibited a close correlation with systolic blood pressure. In DOCA/salt hypertensive rats after 5 weeks and in DOCA/salt SHRs in which significant over-expression of ET-1 was present in blood vessels, vascular morphometr...Continue Reading

Citations

Jan 1, 1997·Cardiovascular Drugs and Therapy·C Rosendorff
Oct 30, 1998·European Journal of Clinical Investigation·P E MassartJ Donckier
Dec 14, 1999·Current Opinion in Nephrology and Hypertension·M Barton, T F Luscher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.