Enhanced expression of human Ia antigens by chronic lymphocytic leukemia cells following treatment with 12-O-tetradecanoylphorbol-13-acetate

European Journal of Immunology
K GuyC M Steel

Abstract

Using a panel of monoclonal antibodies which detect framework determinants of human-Ia alpha and beta polypeptides and the DC-specific monoclonal antibody Genox 353, the in vitro effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of Ia antigens by cells from chronic lymphocytic leukemia (CLL) patients have been studied. In all subjects studied a great increase in expression of framework Ia determinants was found following culture of CLL cells for 90 h with TPA at 10(-7) g/ml. TPA treatment of CLL cells also induced increased expression of Genox 353+ antigens, in some cases where Genox 353 binding was either negligible or not detectable in cells cultured in the absence of TPA.

References

Dec 1, 1978·The Journal of Experimental Medicine·R TosiD Pressman
Jul 1, 1980·Tissue Antigens·F M BrodskyW F Bodmer
Jan 1, 1981·Tissue Antigens·W F Bodmer
Feb 1, 1983·European Journal of Immunology·R A NewmanH Festenstein
Jan 1, 1982·Immunogenetics·V van HeyningenC M Steel

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Citations

Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C R HumeJ S Lee
Dec 1, 1985·European Journal of Immunology·J P FermandJ C Brouet

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