Enhanced expression of IL-34 in an inflammatory cyst of the submandibular gland: a case report

Inflammation and Regeneration
Muhammad BaghdadiKen-Ichiro Seino

Abstract

Cysts of the salivary glands are common lesions that occur in the context of various etiologies. Although the diagnostic importance of cysts in salivary gland diseases has been well studied, molecular mechanisms that control the related pathological process remain largely unknown. IL-34 is a novel cytokine that was discovered recently as a tissue-specific ligand of colony stimulating factor-1 receptor. Since its discovery, accumulating evidence has revealed emerging roles of IL-34 in various pathological conditions and has been suggested to correlate remarkably with inflammation. In this study, we report a medical case of an inflammatory cyst within the submandibular gland, through which evaluating the possible involvement of IL-34 in salivary gland disorders. A 37-year-old male patient suffered from a sudden swelling in the right submandibular region, started initially small and had gradually increased in size to reach 3-4 cm in 1 week, accompanied by pain and local fever. Ultrasonography and MRI imaging revealed the existence of a well-defined cystic lesion with sharp borders measuring 39.8 mm × 19.7 mm within the right submandibular gland. The cyst was removed surgically, and the diagnostic decision was determined based on h...Continue Reading

References

Dec 5, 2014·International Journal of Cancer. Journal International Du Cancer·Aude I SégalinyDominique Heymann
May 6, 2017·Journal of Periodontology·G L MartinezE A Boström
Sep 9, 2017·Cytokine·Muhammad BaghdadiKen-Ichiro Seino
Mar 9, 2018·Inflammation and Regeneration·Nanumi HanKen-Ichiro Seino

❮ Previous
Next ❯

Citations

Aug 2, 2018·Journal of Leukocyte Biology·Muhammad BaghdadiKen-Ichiro Seino
Feb 21, 2019·Blood Advances·Muhammad BaghdadiKen-Ichiro Seino
Nov 26, 2019·Immunological Medicine·Takuto KobayashiKen-Ichiro Seino

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.