PMID: 9444361Jan 28, 1998Paper

Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions

Acta Neuropathologica
J A CossinsC J De Groot

Abstract

The pathology of multiple sclerosis (MS) is characterised by breakdown of the blood-brain barrier accompanied by infiltration of macrophages and T cells into the central nervous system (CNS). Myelin is degraded and engulfed by the macrophages, producing lesions of demyelination. Some or all of these mechanisms might involve proteinases, and here we have studied the cellular localisation and distribution of two matrix metalloproteinases (MMPs), MMP-7 (matrilysin) and MMP-9 (92-kDa gelatinase), in the normal human CNS and active demyelinating MS lesions. Cryostat sections of CNS samples were immunostained with antisera to MMP-7 and MMP-9. In addition, non-radioactive in situ hybridisation (ISH) was performed using a digoxygenin-labelled riboprobe to detect the expression of MMP-7. MMP-7 immunoreactivity was weakly detected in microglial-like cells in normal brain tissue sections, and was very strong in parenchymal macrophages in active demyelinating MS lesions. This pattern of expression was confirmed using ISH. MMP-7 immunoreactivity was not detected in macrophages in spleen or tonsil indicating that it is specifically induced in infiltrating macrophages in active demyelinating MS lesions. MMP-9 immunoreactivity was detected in ...Continue Reading

Citations

Dec 3, 1999·Journal of Neuroscience Research·G PeridesM S Klempner
Mar 21, 2006·Acta Neuropathologica·Maria Diaz-SanchezMargaret M Esiri
Nov 19, 2004·Journal of Neurology·Hans-Peter HartungYannis Zoukos
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·F MannelloS Papa
Sep 5, 2013·Acta neurologica Belgica·Mohammad A JavaidZeeshan Sheikh
May 4, 2013·Veterinary Immunology and Immunopathology·Gisele F MachadoErica S Ribeiro
Apr 18, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·M GunnarssonP E Jensen
Jul 20, 2002·Journal of the Neurological Sciences·I NelissenG Opdenakker
Apr 17, 2003·Life Sciences·Ana M KettlunM Antonieta Valenzuela
Jul 20, 2000·Journal of Neuroimmunology·J A EdwardsP J Talbot
Jan 8, 2000·Journal of Neuroimmunology·F SellebjergP Garred
Aug 12, 2003·Brain Research Bulletin·F Sellebjerg, T L Sørensen
Mar 29, 2000·Neuropathology and Applied Neurobiology·P van der Valk, C J De Groot
May 21, 2013·Brain : a Journal of Neurology·Smriti M AgrawalV Wee Yong
Jul 23, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Arek SzklarczykKatherine Conant
Dec 1, 1999·Annals of the Rheumatic Diseases·C LockL Steinman
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·T KanesakaS Kuwabara
Apr 20, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Haoqian ZhangLinda J Noble-Haeusslein
Jul 23, 2013·Molecular Neurobiology·Arash NazeriAmit Bar-Or
Sep 12, 2013·Clinical & Developmental Immunology·Helen Könnecke, Ingo Bechmann
Apr 10, 2002·Acta Neurologica Scandinavica·B G H SchoserH-J Stuerenburg
May 14, 2003·Journal of Neuroimmunology·Catharina M P VosHelga E de Vries
Jul 5, 2005·Expert Opinion on Investigational Drugs·V W Yong
May 3, 2007·Journal of Neurochemistry·Arek SzklarczykKatherine Conant
Aug 14, 2012·Pediatric Neurology·Ünsal YılmazSerdaroğlu Ayşe
Aug 22, 2008·Journal of Neuropathology and Experimental Neurology·Elizabeth GraySeth Love
Oct 7, 2015·Brain, Behavior, and Immunity·Frieder HaenischSabine Bahn
Feb 25, 2011·Research in Veterinary Science·Fatma İlhanMehmet Halıgür

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.