Enhanced expression of parathyroid hormone-related protein in prostate cancer as compared with benign prostatic hyperplasia

Human Pathology
F K AsadiS C Kukreja

Abstract

Parathyroid hormone-related protein (PTHrP) has been shown to be the primary factor responsible for humoral hypercalcemia of malignancy. Recently PTHrP has been shown to be an early-response gene that may be involved in cellular proliferation or differentiation. In addition, PTHrP has been implicated in the pathogenesis of bone metastases. Bone metastases are a significant complication in patients with prostate cancer. We compared the expression of PTHrP by immunohistochemical staining using a monoclonal antibody directed against epitope between amino acids [53-64] in benign prostatic hyperplasia (BPH) with that in various stages of prostate cancer. Tissue sections were obtained on formalin-fixed paraffin-embedded blocks from BPH, well-differentiated prostate cancer, poorly differentiated prostate cancer, lymph node metastases (n = 15 each), and normal prostate (n = 2). In the normal prostate tissue there was no staining observed. In BPH, 13 of 15 tissue samples were positive for PTHrP immunoreactivity. An average of 33% of the cells stained positive with 1+ intensity. All samples from prostate cancer stained positive for PTHrP. In the samples from well-differentiated prostate cancer, an average of 87% of cells stained positive...Continue Reading

Citations

Dec 17, 2008·Molecular Medicine·Zacharoula PanteleakouMichael Koutsilieris
Jul 27, 2012·Future Oncology·Fabiana N SokiLaurie K McCauley
Jan 5, 2005·Biochemical and Biophysical Research Communications·Leonard J DeftosJack Geller
May 24, 2011·Cancers·Megan N ThobeCarrie W Rinker-Schaeffer
Jan 1, 2013·Cancer Growth and Metastasis·Sathana DushyanthenGerald M Y Quan
Dec 13, 2006·Cancer Metastasis Reviews·Michel B ChoueiriSue-Hwa Lin
Dec 14, 2006·Cancer Metastasis Reviews·Jinhui Liao, Laurie K McCauley
Nov 18, 2008·Endocrine·Bandana ChakravartiNaibedya Chattopadhyay
Aug 15, 1998·Pathology International·F MasuiK Fujii
Jan 29, 2010·Cancer·Toni IbrahimDino Amadori
Jun 9, 1998·Japanese Journal of Cancer Research : Gann·A TakaokaK Imai
Jun 15, 2004·Prostate Cancer and Prostatic Diseases·A A G BrydenN W Clarke
Sep 27, 2001·Japanese Journal of Cancer Research : Gann·N SekitaH Ito
Mar 13, 2002·Drugs & Aging·R C PelgerN A Hamdy
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Volker WollscheidMatthias Dürst
Apr 17, 2003·The Oncologist·Michael J Morris, Howard I Scher
Nov 10, 2001·American Journal of Physiology. Endocrinology and Metabolism·J L SandersE M Brown
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·S A RabbaniD Goltzman
Nov 24, 2020·Frontiers in Bioengineering and Biotechnology·Imane Ait OumgharPatrick Chabrand
Feb 13, 2003·Molecular and Cellular Endocrinology·Xiaoli Shen, Miriam Falzon

❮ Previous
Next ❯

Related Concepts

Related Feeds