Enhanced expression of plasminogen activator inhibitor 1 in patients with nephrotic syndrome

Nephron
Yukiko YoshidaK Dohi

Abstract

Hypercoagulability is present in patients with nephrotic syndrome. However, alterations in coagulation and fibrinolysis reflected in the glomeruli and urine are not fully understood. We examined plasma and urine concentrations of tissue-type plasminogen activator (tPA) and type 1 plasminogen activator inhibitor (PAI-1) in 33 patients with nephrotic syndrome (nephrotic group). We compared these concentrations with the concentrations in 30 nonnephrotic patients with chronic glomerulonephritis (nonnephrotic group) and with the concentrations in 30 healthy volunteers (control group). We also examined fibrin/fibrinogen degradation products in serum and urine and plasma D-dimers. The expression of tPA and PAI-1 was examined in isolated glomeruli using RT-PCR methods. Deposition of fibrinogen/fibrin-related antigen was observed by direct immunofluorescence. The incidence of fibrinogen/fibrin-related antigen deposition in the nephrotic group was significantly higher than that in the nonnephrotic group. The concentrations of fibrin/fibrinogen degradation products in serum and urine and of plasma D-dimers were significantly elevated in the nephrotic group as compared with the nonnephrotic and control groups. The plasma concentrations of ...Continue Reading

Citations

Mar 22, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pankaj V Deshpande, Mark Griffiths
Mar 8, 2013·The New England Journal of Medicine·Joseph Loscalzo
May 16, 2014·International Journal of Nephrology·Aibek E MirrakhimovNasir Hussain
Apr 17, 2010·Néphrologie & thérapeutique·Didier Ducloux
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kazumasa HamanoKazuhiro Dohi
Jul 2, 2005·Thrombosis Research·Rajni Singhal, K Scott Brimble
Feb 13, 2017·Thrombosis Research·Silvia Hoirisch-Clapauch, Antonio E Nardi

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