PMID: 8603774Apr 1, 1996Paper

Enhanced expression of platelet-derived growth factor-beta receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy

Diabetes
T InabaN Yamada

Abstract

Coronary heart disease is a major complication of diabetic subjects, and platelet-derived growth factor (PDGF) has been implicated in the development of atherosclerosis. We investigated the effects of high glucose on expression of PDGF-beta receptor. In a binding assay with 125I-labeled PDGF-BB homodimer, high concentrations of glucose increased high-affinity binding of PDGF-BB on human monocyte-derived macrophages and rabbit aortic medial smooth muscle cells. Northern blot analysis confirmed the enhanced effect of glucose on expression of PDGF-beta receptor mRNA in human monocyte-derived macrophages. The protein kinase C inhibitor, staurosporin, completely suppressed an increase in PDGF-BB binding by high glucose, and high glucose significantly activated protein kinase C. These results indicated that PDGF-beta receptor expression was enhanced by high glucose through the activation of protein kinase C. Furthermore, we observed similar effects of high glucose on both PDGF-beta receptor expression and protein kinase C activation in rat mesangial cells and human capillary endothelial cells. Our results suggest that stimulation of the PDGF system is significantly involved in the development not only of diabetic atherosclerosis but ...Continue Reading

Citations

Apr 12, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hai LiLi-Yang Dai
Apr 5, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hai LiLi-Yang Dai
May 12, 2000·Journal of the American College of Cardiology·J SchoferD G Mathey
Aug 5, 1999·Kidney International·G Wolf, F N Ziyadeh
Sep 8, 2000·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·K D Reeves, K Hassanein
Oct 11, 2007·Diabetes, Obesity & Metabolism·Sayeeda RahmanAbdul Rahman A Rashid
May 1, 1997·The Journal of Clinical Investigation·R G TiltonJ R Williamson
Jun 15, 2006·International Archives of Allergy and Immunology·Tetsuya AdachiKen Ohta
Feb 17, 2001·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·T KosakaK Yamamoto
Dec 29, 2009·Journal of Molecular and Cellular Cardiology·Magda Descorbeth, Madhu B Anand-Srivastava
Mar 25, 2004·The American Journal of Pathology·Jennifer L Wilkinson-BerkaRichard E Gilbert
Nov 21, 2015·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Mohammad Ali SadiqYasir Jamal Sepah
Sep 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·Y IkedaK Hashimoto
Jun 23, 2004·Cytokine & Growth Factor Reviews·James C Bonner
May 11, 2005·Biochemical and Biophysical Research Communications·Naoto SekiYasushi Saito
Jul 2, 2005·Expert Opinion on Investigational Drugs·R G TiltonT A Brock
Jul 15, 2005·Expert Opinion on Pharmacotherapy·Reuven Mader
May 10, 2016·Canadian Journal of Diabetes·Vian PeshdaryAlexander Sorisky
Jun 1, 2000·Kidney International. Supplement·S Klahr, J J Morrissey
Apr 1, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Hideaki Bujo, Yasushi Saito
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J ChristopherA A Jaffa
Feb 28, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Markus LassilaMark E Cooper
Nov 6, 2013·Nature Reviews. Rheumatology·Reuven MaderDan Buskila

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Robyn G LanghamNapier M Thomson
© 2021 Meta ULC. All rights reserved