Enhanced extrinsic innervation of nasal and oral chemosensory mucosae in keratin 14-NGF transgenic mice

Cell and Tissue Research
S TakamiT V Getchell

Abstract

The role of nerve growth factor (NGF) in neurotrophic support for the extrinsic innervation of the nasal and oral mucosae was investigated in keratin 14 (K14) - NGF transgenic mice in which NGF was overexpressed in K14-synthesizing cells. K14 immunoreactivity was localized in the epithelial basal cells of the whisker pad skin, the hard palate, the floor of the ventral meatus, and the anterior tongue that are stratified squamous epithelia, and also in basal cells of the vomeronasal, olfactory, and respiratory epithelia that are non-stratified epithelia. In transgenic mice, NGF expression was identified and confined primarily to the basal cells of stratified epithelia. The nasal mucosae including the vomeronasal, olfactory, and respiratory mucosae, and the glands associated with the vomeronasal organ received a greater innervation of protein gene product 9.5-immunoreactive extrinsic fibers in transgenic animals than nontransgenic controls. An increased density of calcitonin gene-related peptide-immunoreactive extrinsic fibers was observed in the nonsensory epithelia of the vomeronasal organ, the olfactory sensory and respiratory epithelia in transgenic animals. Our results indicated that the hyperinnervation of the nasal and oral...Continue Reading

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Citations

Sep 16, 1996·The Journal of Comparative Neurology·N S KrishnaT V Getchell
Mar 3, 1998·Progress in Neurobiology·T Cowen, I Gavazzi
Jan 23, 2009·Anatomical Science International·Rumi HasegawaFumiaki Nishiyama
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Nov 14, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Shigeru TakamiFumiaki Nishiyama
May 6, 2004·Brain Research. Developmental Brain Research·Lixin FanBruce Oakley
Sep 26, 1997·The Journal of Comparative Neurology·V A BotchkarevR Paus
May 12, 2017·International Journal of Molecular Sciences·Gaetana MinnoneLuisa Bracci-Laudiero

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