PMID: 7336436Jan 1, 1981Paper

Enhanced fecal elimination of stored hexachlorobenzene from rats and rhesus monkeys by hexadecane or mineral oil

Toxicology
K RozmanH Greim

Abstract

The effect of various dietary treatments on the fecal excretion of [14C]-hexachlorobenzene (HCB) was studied in rats and rhesus monkeys. Cholestyramine and sesame oil failed to influence fecal excretion of HCB and/or metabolites. However, dietary administration of n-hexadecane (5%) increased fecal excretion of radioactivity 4-13-fold in rats and rhesus monkeys. Similarly, mineral oil in the diet (5%) of rhesus monkeys elicited a 6-9-fold increase in fecal excretion of HCB and/or metabolites. As a result of the mineral oil treatment, and enhanced depletion of HCB from blood and also of the stored HCB from adipose tissue was observed. The concentration of HCB in the blood declined in accordance with decreasing storage levels of HCB in adipose tissue. The major site of elimination of HCB and/or metabolites seemed to be the intestine; in particular, the cecum and the colon ascendens. Both hexadecane and mineral oil appeared to stimulate specifically this elimination path way.

References

Jun 1, 1972·Bulletin of Environmental Contamination and Toxicology·M Gilbertson, L M Reynolds

❮ Previous
Next ❯

Citations

Jan 1, 1984·Bulletin of Environmental Contamination and Toxicology·K RozmanG S Smith
Sep 15, 1984·Toxicology and Applied Pharmacology·E Scheufler, K Rozman
May 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G J Ikeda, P P Sapienza
Aug 1, 1982·Journal of Toxicology and Environmental Health·T RozmanH Greim
Jan 1, 1984·Journal of Toxicology and Environmental Health·E Scheufler, K K Rozman
Sep 30, 1999·Environmental Health Perspectives·C C MichielsenJ G Vos
Jan 1, 1981·Drug and Chemical Toxicology·T RozmanH Greim
Jan 1, 1983·Drug and Chemical Toxicology·K RozmanT Rozman
Jun 1, 1983·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E RichterB Fichtl
Oct 30, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ronald J JandacekPatrick Tso
Mar 6, 2003·Journal of Agricultural and Food Chemistry·Yoko Nakashima, Sachie Ikegami
Aug 22, 2002·Environmental Science & Technology·G Andreas Moser, Michael S McLachlan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.