Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy

ACS Nano
Tian XuSiwen Li

Abstract

Photodynamic therapy (PDT) combined with oxygenating strategies is widely employed in cancer treatment; however, oxygen-boosted PDT has failed to achieve an ideal effect due to the complexity, heterogeneity, and irreversible hypoxic environment generated by tumor tissues. With the emergence of Fe-dependent ferroptosis boasting reactive oxygen species (ROS) cytotoxicity as well, such a chemodynamic approach to cancer therapy has drawn extensive attention. In this study, hemoglobin (Hb) is connected with the photosensitizer chlorin e6 (Ce6) to construct a 2-in-1 nanoplatform (SRF@Hb-Ce6) with Sorafenib (SRF, ferroptosis promotor) loaded, combining oxygen-boosted PDT and potent ferroptosis. Benefiting from the intrinsic presence of Fe capable of binding oxygen, hemoglobin concurrently furnishes oxygen for oxygen-dependent PDT and Fe for Fe-dependent ferroptosis. Furthermore, amphiphilic MMP2-responsive peptide is incorporated into the skeleton of the nanoplatform to ensure drug-release specificity for safety improvement. Correlative measurements demonstrate the potentiation of PDT and ferroptosis with SRF@Hb-Ce6. More importantly, PDT strengthens ferroptosis by recruiting immune cells to secrete IFN-γ, which can sensitize the tumo...Continue Reading

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Citations

Feb 14, 2021·Biomaterials·Fangmin ChenHaijun Yu
Feb 13, 2021·Oxidative Medicine and Cellular Longevity·Yue ChengXiaojing Liu
Jan 13, 2021·Journal for Immunotherapy of Cancer·Razan AlzeibakDmitri V Krysko
Oct 13, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sena KaraosmanogluXianfeng Chen
Mar 4, 2021·Biomedical Materials·Xiaqing Wu, Haiyuan Zhang
Mar 1, 2021·Trends in Cancer·Tatiana A MishchenkoDmitri V Krysko
Apr 1, 2021·ACS Applied Materials & Interfaces·Ping DongXiaoqing Liu
May 18, 2021·Frontiers in Cell and Developmental Biology·Haiyang WuZhiming Sun
May 25, 2021·Chemical Society Reviews·Yuxuan XiongXiangliang Yang
Jun 30, 2021·Journal of Nanobiotechnology·Jingqi XinFeifei An
Sep 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qun GuanYu-Bin Dong
Sep 29, 2021·Advanced Materials·Yilin WanPeng Huang
Nov 4, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiaoyang TaoWeidong Fei

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