Enhanced fibrinolysis caused by tissue plasminogen activator release in hemodialysis

Kidney International
W SpeiserB R Binder

Abstract

The effect of hemodialysis on components of the fibrinolytic system was measured in 22 patients. Plasma levels of t-PA antigen, t-PA activity, u-PA antigen and plasminogen activator inhibitor were determined by means of immunological and functional assays. During hemodialysis, 11 patients exhibited an increase in t-PA antigen within the first hour to about three times the starting values (P less than 0.05), followed by a decrease to about double of the initial values until the end of the treatment. Eleven patients showed a continuous increase up to 200% of the starting values until the end of hemodialysis. u-PA levels did not change significantly during the time of investigation (P greater than 0.5).

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Citations

May 20, 2003·Seminars in Dialysis·Liam F Casserly, Laura M Dember
Jul 4, 2009·Seminars in Dialysis·Miriam GalbuseraPaola Boccardo
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Related Concepts

Teens
Fibrinolysis
Neoglycoproteins
Hemodialysis
Actilyse
Uremia
Kidney Plasminogen Activator
Plasminogen Activator Inhibitors, Placental

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