PMID: 11606010Oct 19, 2001Paper

Enhanced flow-dependent vasodilatation after bed rest, a possible mechanism for orthostatic intolerance in humans

European Journal of Applied Physiology
P BonninB I Levy

Abstract

We investigated the alteration in flow-dependent-dilatation in the orthostatic intolerance occurring after bed-rest deconditioning. Eight men [aged mean (SEM) 32 (2) years] underwent two consecutive periods of 7 days of head-down-tilt (HDT, -6 degrees) during bed rest. A control age and sex matched group [n = 8, 30 (2) years], maintained its usual physical activity. Blood flow velocity (BFV) and diameter (Doppler and echotracking systems) were measured in the brachial artery, under basal conditions and during the post ischaemic hyperaemia following occlusion. The increase in BFV post-ischaemia did not change before, during and after HDT but the relative increase in the diameter was greater on the 7th day of the HDT period than before HDT [+8.8(1.6)% compared to +3.7(1.0)%, P < 0.001]. After HDT, 11 of 16 standing tests (comprising eight subjects in the two HDT periods) had to be stopped because of orthostatic intolerance. The flow-dependent-dilatation measured at the end of HDT was negatively correlated with the post-bed-rest duration of orthostatic tolerance (r = 0.78, P < 0.01). After the sublingual administration of glyceryl trinitrate, there was no change in the increase in diameter. No significant changes were observed in ...Continue Reading

Citations

Jul 31, 2007·European Journal of Applied Physiology·A Pavy-Le TraonJ Vernikos
Nov 28, 2009·European Journal of Applied Physiology·Dick H J ThijssenDaniel J Green
Mar 13, 2010·European Journal of Applied Physiology·Mahmoud A AlomariMichael A Welsch
Oct 12, 2012·European Journal of Applied Physiology·Gurpreet K BirkDick H J Thijssen
May 5, 2010·Cleveland Clinic Journal of Medicine·Juan J FigueroaPhillip A Low
Apr 2, 2005·The Journal of Physiology·Michiel W P BleekerPaul Smits
Oct 27, 2007·The Journal of Physiology·D H J ThijssenM T E Hopman
Dec 22, 2007·The Journal of Physiology·M KooijmanM T E Hopman
Apr 22, 2009·Respiratory Physiology & Neurobiology·M CoupéM A Custaud
Feb 14, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Jose-Alberto PalmaHoracio Kaufmann
Apr 26, 2006·Archives of Physical Medicine and Rehabilitation·Patricia C de GrootMaria T Hopman
Mar 31, 2006·Archives of Physical Medicine and Rehabilitation·Dick H ThijssenMaria T Hopman
Feb 18, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Dominique DeplanqueUNKNOWN Lacunar-BICHAT Investigators
Feb 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Patricia C E de GrootMaria T E Hopman
Jun 10, 2010·Hypertension·Noortje T L van DuijnhovenDick H J Thijssen
Mar 17, 2009·Stroke; a Journal of Cerebral Circulation·Philippa C LavalléeUNKNOWN Lacunar-BICHAT Investigators
Dec 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Michiel W P BleekerMaria T E Hopman
Aug 16, 2005·Journal of Applied Physiology·Christiane HesseWalter E Haefeli
Aug 25, 2005·Medicine and Science in Sports and Exercise·Patricia de GrootMaureen MacDonald
Dec 4, 2003·Medicine and Science in Sports and Exercise·Patricia C E De GrootMaria T E Hopman
Oct 21, 2017·Nature Reviews. Cardiology·Richard L HughsonMarco Durante
May 28, 2019·Experimental Physiology·Ryan S GartenAndrew Mcintyre
Nov 28, 2019·European Journal of Pediatrics·Karsten KönigsteinArno Schmidt-Trucksäss
Sep 4, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Claire DemiotMarc-Antoine Custaud
Jul 9, 2011·Journal of Applied Physiology·Dick H J ThijssenMaria T E Hopman
Jun 12, 2020·Journal of Applied Physiology·Stuart M C LeeMichael B Stenger
Sep 26, 2020·Frontiers in Physiology·Nastassia NavasiolavaMarc-Antoine Custaud

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