Enhanced functional recovery in MRL/MpJ mice after spinal cord dorsal hemisection.

PloS One
Sandrine ThuretFred H Gage

Abstract

Adult MRL/MpJ mice have been shown to possess unique regeneration capabilities. They are able to heal an ear-punched hole or an injured heart with normal tissue architecture and without scar formation. Here we present functional and histological evidence for enhanced recovery following spinal cord injury (SCI) in MRL/MpJ mice. A control group (C57BL/6 mice) and MRL/MpJ mice underwent a dorsal hemisection at T9 (thoracic vertebra 9). Our data show that MRL/MpJ mice recovered motor function significantly faster and more completely. We observed enhanced regeneration of the corticospinal tract (CST). Furthermore, we observed a reduced astrocytic response and fewer micro-cavities at the injury site, which appear to create a more growth-permissive environment for the injured axons. Our data suggest that the reduced astrocytic response is in part due to a lower lesion-induced increase of cell proliferation post-SCI, and a reduced astrocytic differentiation of the proliferating cells. Interestingly, we also found an increased number of proliferating microglia, which could be involved in the MRL/MpJ spinal cord repair mechanisms. Finally, to evaluate the molecular basis of faster spinal cord repair, we examined the difference in gene ex...Continue Reading

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Methods Mentioned

BETA
confocal microscopy
in vitro transcription
chip
PCR
chips
ubiquitination
dissection

Software Mentioned

Primer Express
dChip
XLSTAT
Sequence Detector Systems
Excel
StereoInvestigator
Affymetrix Microarray Analysis Suite ( MAS )

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