PMID: 9178035Apr 1, 1997Paper

Enhanced GABA release in cell-damaging conditions in the adult and developing mouse hippocampus

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
P Saransaari, S S Oja

Abstract

The release of [3H]GABA from hippocampal slices from adult (3-month-old) and developing (7-day-old) mice was studied in cell-damaging conditions in vitro using a superfusion system. Cell damage was induced by modified superfusion media, including hypoxia, hypoglycemia, ischemia, the presence of Free radicals and oxidative stress. The basal release of GABA from the immature and mature hippocampus was generally markedly increased in all cell-damaging conditions. In 7-day-old mice the release was enhanced most in the presence of free radicals. 1.0 mM NaCN and ischemia, whereas in the adults 1.0 mM NaCN provoked the largest release of GABA, followed by ischemia and free radical-containing media. Potassium stimulation (50 mM K+) was still able to potentiate the release in all cell-damaging conditions in both age groups. It was shown by superfusing the slices in Ca- and Na-free media that ischemia-induced GABA release was Ca-independent, occurring by a reversed operation of Na-dependent cell membrane carriers in both adult and developing hippocampus. Glutamate and its receptor agonists, N-methyl-D-aspartate (NMDA), kainate and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), potentiated GABA release only in the immature hippo...Continue Reading

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Citations

Sep 23, 2008·Metabolic Brain Disease·J W PanD D Spencer
May 9, 2012·Reviews in Endocrine & Metabolic Disorders·Joseph Nuñez
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Oct 12, 2014·Neuroscience Letters·E Hernández-AndradeA Molina-Hernández
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Aug 23, 2007·Neurochemical Research·Pirjo Saransaari, Simo S Oja
Oct 18, 2007·Neurochemical Research·Pirjo Saransaari, Simo S Oja

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