Enhanced gene delivery using Bubble liposomes and ultrasound for folate-PEG liposomes

Journal of Drug Targeting
Daiki OmataYukihiko Aramaki

Abstract

We have previously reported that the transfection efficiency of laminin-derived AG73-peptide labeled polyethyleneglycol-modified liposomes (AG73-PEG liposomes) was enhanced by echo-contrast gas entrapping PEG liposomes (Bubble liposomes, BLs) and ultrasound (US) exposure by improving endosomal escape. However, it has not been well understood whether BLs and US exposure can enhance the transfection efficiency of other carriers except AG73-PEG liposomes. In this study, to evaluate whether BLs and US exposure can be generally applied to gene delivery carriers, we focused on folate as a model ligand and examined whether BLs and US exposure could enhance the transfection efficiency of folate-PEG liposomes. Folate-PEG liposomes could internalize into cells efficiently, whereas they could not deliver genes into cytosol from endosomes sufficiently. BLs and US exposure could enhance the transfection efficiency of folate-PEG liposomes compared with folate-PEG liposomes alone without their direct induction into cells. These results suggested that BLs and US exposure could enhance the transfection efficiency of folate-PEG liposomes in the same manner as AG73-PEG liposomes. Thus, BLs and US exposure may be a promising tool to achieve effici...Continue Reading

References

Jun 2, 1987·Biochemistry·N K SubbaraoK Pongracz
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guangfeng ShiRobert J Lee
Apr 8, 2003·Current Medicinal Chemistry·Aaron HirkoJeffrey A Hughes
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Junhwa ShinDavid H Thompson
Aug 29, 2003·The Journal of Biological Chemistry·N D SonawaneA S Verkman
Jan 7, 2004·Advanced Drug Delivery Reviews·Anders HøgsetKristian Berg
Nov 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shubiao ZhangZongshi Li
Feb 25, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Greg F WalkerErnst Wagner
Dec 21, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Susumu HamaHideyoshi Harashima
Feb 16, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomomi YoshidaYukihiko Aramaki
Nov 3, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Soo Hyeon LeeTae Gwan Park
Dec 26, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yun ZhouCheri X Deng
Apr 5, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shyh-Dar LiLeaf Huang
Sep 23, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoichi NegishiYukihiko Aramaki
Nov 18, 2008·Ultrasound in Medicine & Biology·R E KumonC X Deng
Dec 25, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maarja MäeUlo Langel
Feb 26, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Quinn K T NgTatiana Segura
Jun 23, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hiroto HatakeyamaHideyoshi Harashima
Nov 4, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ryo SuzukiKazuo Maruyama
Dec 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Swati KoppuChristine Dufès
Oct 12, 2010·Biological & Pharmaceutical Bulletin·Yoichi NegishiYukihiko Aramaki
Jan 20, 2011·The Journal of Biological Chemistry·Benjamin Lelouvier, Rosa Puertollano
Feb 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Seiichi YamanoJin K Montclare
Mar 31, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Golam KibriaHideyoshi Harashima

❮ Previous
Next ❯

Citations

Apr 23, 2013·World Journal of Microbiology & Biotechnology·Xiaoqi SunBolin Zhang
Feb 12, 2013·Biomacromolecules·Rahul NahireSanku Mallik
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Ghaleb A HusseiniAna M Martins
Dec 13, 2012·Expert Opinion on Drug Discovery·Pascal Richette, Ricardo Garay
Aug 31, 2012·Expert Opinion on Drug Delivery·Ricardo P GarayPascal Richette
Jan 11, 2017·Ultrasonics Sonochemistry·Wei-Hao LiaoWen-Shiang Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.