Enhanced gene expression of transforming growth factor-alpha and c-met in rat urinary bladder cancer

Urological Research
M InuiF Wada

Abstract

To investigate the roles of growth factors in bladder cancer, changes in the expression of messenger RNAs (mRNAs) for several growth factors and their receptors were examined during rat bladder carcinogenesis induced with N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN). Northern blot analysis showed that the contents of mRNAs for transforming growth factor-alpha (TGF-alpha) and c-met/hepatocyte growth factor (HGF) receptor increased with BBN treatment. Epidermal growth factor (EGF) receptor mRNA was hardly affected by the treatment; while mRNA for fibroblast growth factor (FGF) receptor 1 and transforming growth factor-beta (TGF-beta) type II receptor decreased with BBN treatment. A rat bladder tumor cell line, NBT-II, expressed both TGF-alpha and c-met mRNAs, and HGF showed apparent scattering and growth-stimulating effects on the cells. These results indicate the possibility that TGF-alpha produced by a bladder cancer, in addition to urinary EGF, plays a role in the development of bladder cancer, and that enhanced cell motility due to activation of the c-met/HGF receptor participates in the invasion and metastasis of the cancer cells.

References

Jan 1, 1992·Urologia Internationalis·D E Neal, K Mellon
Oct 1, 1992·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·S GiordanoP M Comoglio
Jan 31, 1992·Biochemical and Biophysical Research Communications·K YanagitaT Nakamura
Jan 1, 1991·Annals of the New York Academy of Sciences·D BarritaultJ P Caruelle
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K TashiroT Nakamura
May 1, 1989·British Journal of Cancer·K ImanishiK Abe
Jan 15, 1988·Biochemical and Biophysical Research Communications·A C JohnsonI Pastan
Jun 10, 1988·Nucleic Acids Research·T KurokawaK Igarashi
Jun 1, 1994·International Journal of Urology : Official Journal of the Japanese Urological Association·X ZhangI Takenaka
Dec 23, 1993·Biochimica Et Biophysica Acta·J S RubinS A Aaronson
Aug 19, 1993·International Journal of Cancer. Journal International Du Cancer·H KuniyasuE Tahara
Mar 31, 1993·Biochemical and Biophysical Research Communications·K TsuchidaW W Vale
Feb 3, 1993·Journal of the National Cancer Institute·M NguyenJ Folkman

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Citations

Oct 23, 2014·Journal of Translational Medicine·Brian K McNeilDonald P Bottaro
Jun 3, 2000·Japanese Journal of Cancer Research : Gann·S HigashiH Hiai
Nov 25, 1997·Japanese Journal of Cancer Research : Gann·N NishiF Wada
Feb 19, 2017·Cell Communication and Signaling : CCS·Ralf HassKarlheinz Friedrich
Jan 19, 2018·International Journal of Molecular Sciences·Marzena Wyganowska-ŚwiątkowskaJerzy Jankun
Mar 30, 2007·Radiation Research·Anna S E LjungkvistAlbert J van der Kogel
May 29, 1998·Journal of Clinical Pathology·M J ArendsM Wells
Oct 10, 2002·Experimental Cell Research·Thomas MüllerJackie Papkoff

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