Enhanced glucose tolerance by intravascularly administered piceatannol in freely moving healthy rats

Biochemical and Biophysical Research Communications
Yukihiro OritaniShoji Takeuchi

Abstract

Piceatannol is a phytochemical in the seeds of passion fruit that has a hypoglycemic effect when orally administered. To elucidate the contribution of intact and metabolites of piceatannol after gastro-intestinal absorption to hypoglycemic effect, we examined the influence of piceatannol and isorhapontigenin on blood glucose concentrations during fasting and glucose tolerance tests by administering them intravascularly to freely moving healthy rats. We found that intravascularly administered piceatannol reduced the blood glucose concentrations during both fasting and glucose tolerance tests, but isorhapontigenin did not during either of them. Furthermore, we found that piceatannol increased the insulinogenic index during glucose tolerance tests and that piceatannol had no influence on insulin sensitivity by performing hyperinsulinemic euglycemic clamping tests. These results suggest that piceatannol orally intaken may enhance glucose tolerance by the effect of intact piceatannol through enhanced early-phase secretion of insulin. Therefore, oral intake of piceatannol might contribute to proper control of postprandial glycemic excursions in healthy subjects.

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Citations

Apr 15, 2016·Journal of Agricultural and Food Chemistry·Hiroyuki InagakiTatsuhiko Ito
Apr 8, 2017·Journal of Medicinal Food·Jonathan Kershaw, Kee-Hong Kim
Oct 3, 2019·Biomolecules·Bahare SalehiJavad Sharifi-Rad
Jul 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Berin Karaman MayackFidele Ntie-Kang

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