Enhanced glutamatergic phenotype of mesencephalic dopamine neurons after neonatal 6-hydroxydopamine lesion

Neuroscience
Gregory Dal BoL-E Trudeau

Abstract

There is increasing evidence that a subset of midbrain dopamine (DA) neurons uses glutamate as a co-transmitter and expresses vesicular glutamate transporter (VGLUT) 2, one of the three vesicular glutamate transporters. In the present study, double in situ hybridization was used to examine tyrosine hydroxylase (TH) and VGLUT2 mRNA expression during the embryonic development of these neurons, and postnatally, in normal rats and rats injected with 6-hydroxydopamine (6-OHDA) at P4 to destroy partially DA neurons. At embryonic days 15 and 16, there was a regional overlap in the labeling of TH and VGLUT2 mRNA in the ventral mesencephalon, which was no longer found at late embryonic stages (E18-E21) and postnatally. In normal pups from P5 to P15, only 1-2% of neurons containing TH mRNA in the ventral tegmental area (VTA) and substantia nigra, pars compacta, also displayed VGLUT2 mRNA. In contrast, after the cerebroventricular administration of 6-OHDA at P4, 26% of surviving DA neurons in the VTA of P15 rats expressed VGLUT2. To search for a colocalization of TH and VGLUT2 protein in axon terminals of these neurons, the nucleus accumbens of normal and 6-OHDA-lesioned P15 rats was examined by electron microscopy after dual immunocytoch...Continue Reading

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Citations

Jan 5, 2012·Neurotoxicity Research·Carlos J BaierMarta C Antonelli
Mar 2, 2010·Médecine sciences : M/S·Dominic ThibaultLouis-Eric Trudeau
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carolina BirgnerAsa Wallén-Mackenzie
Jan 15, 2011·The Journal of Biological Chemistry·Dominic ThibaultLouis-Éric Trudeau
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Jan 9, 2019·Frontiers in Neural Circuits·Louis-Eric Trudeau, Salah El Mestikawy

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